Exploring the Efficacy and protection of issue Xa Inhibitors in Anticoagulation Therapy
Implanted Drug Delivery Systems for Control of Chronic Pain
Orally Disintegrating Tablets (ODTs) and Related Tablet Formulations,
Design and Development of Bandages Using Alginate from sargassum Species
Scientific Literacy and Attitude: A Study of Their Interdependent Effects on Science
The Perspective View about Water Hyacinth as Problem or Resource: A Review
The Role of Stilbene Phytoalexins in the Resistance Mechanism of Grapevine Against Plasmopara Viticola
Susceptibility of Multidrug Resistant Bacteria to Lyophilized Citrus Limon Juice Extract
Neem Root Mediated-Biosynthesis of Silver Nanoparticles: Antimicrobial Activities and Application as Detergent Additive
Natural Phyto-Constituents as Leishmanicides: A Brief Review of the Most Widely Recommended Phyto Chemicals of the 21st Century and an Account of their Mode of Action
Diversity Assessment of Insect Species in the Kariavattom Campus, University of Kerala
Scientific Literacy and Attitude: A Study of Their Interdependent Effects on Science
A Comprehensive Analysis of Covid-19: An Overview
Pediatric Drug Formulation
Neem Root Mediated-Biosynthesis of Silver Nanoparticles: Antimicrobial Activities and Application as Detergent Additive
Factor Xa inhibitors are a class of anticoagulants that focus on issue Xa, a vital element in the blood coagulation cascade. This overview goals to provide a complete evaluation of the pharmacology, scientific applications, and safety concerns of Xa inhibitors, such as apixaban, rivaroxaban, and edoxaban. those medications have tested efficacy in stopping stroke and systemic embolism in sufferers with atrial traumatic inflammation, as well as treating and stopping venous thromboembolism. The Xa inhibitors offer several advantages over traditional anticoagulants, together with warfarin, along with predictable pharmacokinetics, fast onset of movement, and fewer interactions with food and other medicinal drugs. however, their use calls for careful attention to affected person-particular factors, such as renal characteristics and concomitant medicinal drugs, to optimize safety and efficacy. The review highlights the importance of expertise in the pharmacological residences of each Xa inhibitor, including renal clearance, half-existence, and capacity drug interactions. additionally, it discusses the medical trial data supporting their use in diverse affected person populations and the management of bleeding complications. overall, this review offers an in-depth examination of the position of Xa inhibitors in contemporary anticoagulation therapy, highlighting their benefits and limitations, and providing steerage for his or her secure and powerful use in medical practice.
Implanted drug delivery systems (IDDS) have emerged as a promising strategy for managing chronic pain, offering precise and sustained drug administration to achieve optimal pain relief while minimizing adverse effects. This abstract reviews the key aspects of IDDS in the context of chronic pain control. Chronic pain, characterized by its persistence over extended periods, presents a significant challenge in medical practice due to its complex and multifaceted nature. Traditional oral medication often falls short of providing consistent pain relief while avoiding systemic side effects. IDDS addresses these limitations by delivering drugs directly to the target site, bypassing first-pass metabolism, and maintaining steady therapeutic concentrations. IDDS consists of an implantable device that houses a reservoir of the chosen medication, connected to a catheter for drug release. The release rate can be programmed and adjusted according to the patient's needs. Commonly used drugs include opioids, local anesthetics, and anti-inflammatory agents. The implantation procedure requires surgical expertise but offers the advantage of long-term pain management, reducing the need for frequent dosing. The efficacy of IDDS in chronic pain control has been demonstrated in various conditions such as cancer pain, neuropathic pain, and failed back surgery syndrome. By providing sustained drug delivery, IDDS ensures consistent pain relief, potentially improving patients' quality of life and reducing the development of tolerance and dependence. However, challenges include the risk of infection, device malfunction, and the invasiveness of the implantation procedure.
Orally disintegrating tablets (ODTs) represent a widespread advancement in drug delivery, in particular for patients with swallowing problems, together with the elderly aged and pediatric populations. Those formulations dissolve or disintegrate swiftly inside the mouth, allowing the drug to be absorbed without the need for water, enhancing affected patient compliance, and supplying convenient dosing. The improvement of ODTs carries various strategies, which include freeze-drying, direct compression, and sublimation, every designed to optimize the rapid disintegration and bioavailability of the energetic pharmaceutical factor (API). Key demanding situations in the ODT formula include attaining a sensitive balance between pill hardness and porosity to preserve mechanical integrity even ensuring rapid dissolution. This calls for the careful choice of excipients such as super disintegrates, which boost up the breakup of the tablet, and binders that provide structural support. Advanced methods, consisting of 3D printing and nanotechnology, also are being explored to enhance the customization and efficiency of ODTs for personalized medication. The blessings of ODTs extend beyond patient convenience, as additionally, they facilitate quicker onset of motion and extra therapeutic effectiveness, particularly for medicines where instantaneous alleviation is vital. However, challenges like stability, taste masking, and packaging remain to impact the improvement and giant use of ODTs. Future studies objectives to cope with those limitations, making ODTs a promising alternative in both acute and chronic treatment plans.
Bandage invention pertains to the field of health sciences, specifically in developing sustainable, bioactive bandages using alginates derived from marine sources. With increasing concerns over environmental contamination from health products, there is a recognized need for sustainable practices in the production and disposal of medicinal materials. Marine-derived alginates, particularly from the Sargassum species, possess unique properties that make them ideal for wound care. These properties include antimicrobial activity, biodegradability, biocompatibility, and the ability to promote wound healing, tissue regeneration, and blood clotting. The porous structure of alginate enhances gas exchange, promotes oxygenation, and prevents bacterial growth, while its antioxidant properties protect wounds from oxidative stress. Additionally, the alginate's scaffold-like structure supports collagen synthesis and cell proliferation, accelerating tissue repair. This invention focuses on creating customized bandages for dry wounds, ensuring effective healing by clearing dead skin and fostering tissue regeneration with minimal environmental impact.
This study sought to explore the relationship between scientific attitude and scientific literacy among secondary and higher-secondary students. Specifically, it aims to examine how scientific literacy impacts students’ attitudes and how scientific attitude influences their literacy levels. Understanding this interdependence is crucial for enhancing educational strategies that promote success in science education. The study used a correlation survey technique. A random sample of 450 secondary and higher secondary students from grades 9th to 12th of Udupi district in Karnataka was selected. Data was gathered using the Test of Scientific Literacy Skills (TSLS) and the Scientific Attitude Test (SAS). All data were analysed using descriptive and inferential statistics, including Pearson correlation and regression analysis to assess the strength of the relationship between variables as well as predictive abilities. There was a significant strong positive relationship between scientific attitude and scientific literacy, r[450 – 2] =.700, p< .001, with each significantly predicting the other. These results indicate that an increase in literacy of science is strongly associated with a more positive attitude toward this field. On the other hand, improvements in science literacy enhance an optimal attitude toward the field. The bidirectional influence indicates that enhancing either construct can create a reinforcing cycle, improving overall student engagement and success in science education. Furthermore, the results highlight the crucial role of nurturing both the cognitive and attitudinal dimensions of science learning, pointing to the need for integrated approaches in science education.
