i-manager's Journal on Chemical Sciences (JCHEM)


Volume 3 Issue 1 January - April 2023

Research Paper

In Vitro Antifungal Activity of the Extracts of Selected Marine Microalgae against Human Pathogens

Rahul Pratap* , Lal Prasanth M. L.**
*-** Dr. Moopen’s College of Pharmacy, Wayanad, Kerala, India.
Pratap, R., and Prasanth, M. L. L. (2023). In Vitro Antifungal Activity of the Extracts of Selected Marine Microalgae against Human Pathogens. i-manager's Journal on Chemical Sciences, 3(1), 1-5. https://doi.org/10.26634/jchem.3.1.19286

Abstract

The present study was designed to screen the biological activities of marine micro algal samples collected along the South Indian coastal belt. For that the marine water samples were collected from different coastal locations such as Colachel, Kadiapattinam and Muttom of Kanyakumari District, South India. The collected sea water sample were filtered, serially diluted, supplemented with Walne's medium and subjected to light incubation under laboratory conditions for two weeks for optimum growth and the algal species were identified and isolated based on their morphological characteristics with the help of light microscope. Totally 10 isolates, 5 from Muttom seawater collection, 3 from Kadiapattinam and 2 from Colachel collections were identified. 5 isolates from the Muttom seawater collection was evaluated further. In this evaluation, the growth pattern of isolated algal species was studied and their mass production was done. The cultured algal species were subjected to centrifugal separation and solvent extraction by using three solvents such as ethyl acetate, methanol and water. The supernatants collected were evaluated for the antimicrobial activity against three fungal pathogens viz., Aspergillus niger, Candida albicans and Mucur sp. In the antimicrobial evaluation, the methanol extract of S–2, S–3, S–4 and S–5 samples showed a significant antimicrobial activity against the tested fungal culture. Our further studies directed toward the identification algal species, phytochemical screening and various detailed pharmacological screening may give more valuable results.

Research Paper

In Vitro Anticancer and Antioxidant Activity Screening of Selected Marine Micro Algal Extracts

Rahul Pratap* , M. L. Lal Prasanth**, Anu V.***
*-*** Dr. Moopen's College of Pharmacy, Kerala, India.
Pratap, R., Prasanth, M. L. L., and Anu, V. (2023). In Vitro Anticancer and Antioxidant Activity Screening of Selected Marine Micro Algal Extracts. i-manager's Journal on Chemical Sciences, 3(1), 6-11. https://doi.org/10.26634/jchem.3.1.19293

Abstract

The present study was aimed to evaluate the anticancer and antioxidant activity of the five algal samples named as S–1 to S–5 isolated from the seawater collection of Muttom coastal region of Kanyakumari District. Mass production of micro algae was done by using sea water containing Walne's medium and each cultivated algae was isolated by centrifugation and extracted with different solvents viz., ethyl acetate, methanol and water. The extracts obtained were evaluated for in vitro anticancer and antioxidant activity. Anticancer activity was evaluated by MTT assay using the cell lines MCF7 and SKMEL. In this evaluation, extracts of all the algal samples showed anticancer activity against the selected cell lines, however, the methanol extract of S–2 sample showed significant activity comparing with other samples. Antioxidant activity was evaluated by DPPH, reducing power assay and superoxide radical scavenging assay methods. In this evaluation also, the methanol extract of S–2 sample showed a significant antioxidant activity in all the tested methods. These results are useful for further investigation in the future.

Research Paper

Phytochemical Characterization of Trichodesma indicum R. Br. Roots for their Biological Properties

Daniel Xavier Prasad*
Sree Krishna College of Pharmaceutical Science and Research Center, Parassala, Trivandrum, Kerala, India
Prasad, D. X. (2023). Phytochemical Characterization of Trichodesma indicum R. Br. Roots for their Biological Properties. i-manager's Journal on Chemical Sciences, 3(1), 12-22. https://doi.org/10.26634/jchem.3.1.19310

Abstract

The aim of this study is to perform a pharmacognostic and phytochemical investigation with the characterization of the isolated compounds in the roots of Trichodesma indicum R. Br. In the isolation of the compounds from petroleum ether and benzene extracts of the roots of Trichodesma indicum, the presence of phytosterol compounds in the petroleum ether extracts was identified. The column chromatography yielded three compounds, namely A, B, and C, in the petroleum ether extract and three compounds, namely D, E, and F, in the benzene extracts. These compounds were characterized by UV, NMR, and IR spectra, along with their physical parameters, and identified as phytosterols. It was found that the root extract showed the presence of various constituents in this study of successive solvent extraction. Petroleum ether and benzene extracts were found to contain fixed oils and lipids. The ethanol and ethyl acetate extracts of the roots of Trichodesma indicum proved the presence of flavonoids and phenolic compounds. Trichodesma indicum has a very good antioxidant effect due to the presence of phytosterols and phenolic compounds, which can be supportive of boosting immune supplements.

Review Paper

Cosmetics Belonging to Alternative Systems of Medicine: A Review

Athira K. B.* , Rahul Pratap**, Lal Prasanth M. L.***, Rajeev V. R.****
*-**** Dr. Moopen's College of Pharmacy, Wayanad, Kerala, India.
Athira, K. B., Pratap, R., Prasanth, M. L. L., and Rajeev, V. R. (2023). Cosmetics Belonging to Alternative Systems of Medicine: A Review. i-manager's Journal on Chemical Sciences, 3(1), 23-31. https://doi.org/10.26634/jchem.3.1.19378

Abstract

Beauty is a divine gift to human beings and its value has been recognized and appreciated since time immemorial, and efforts have been made to preserve and promote beauty in all aspects. It is a subject of socio-medical importance that has been accepted since time immemorial. Along with the increased demand for beautification, problems are also increasing that cause damage to beauty or personality due to changed lifestyles and polluted atmosphere. The concept of beauty and cosmetics is as old as human civilization. In Ayurveda, the concept of beauty has an age-old origin. According to the alternative system of medicine, healthy skin is a result of the overall health condition of individuals, and it prescribes numerous skincare treatments that need to be pursued at every stage of life. This paper provides a review of cosmetics belonging to alternative systems of medicine, with a focus on Ayurveda and its principles. It explores the historical significance of beauty and cosmetics in ancient civilizations, particularly in Indian culture. The use of herbal ingredients and natural substances is highlighted in the paper.

 

Comparative Studies

Comparative Review on Polyherbal and Monoherbal Cosmetic Formulations

Thamanna P.* , Lal Prasanth M. L.**
* Dr. Moopen's College of Pharmacy, Wayanad, Kerala, India.
** Department of Pharmacognosy, Dr. Moopen's College of Pharmacy, Wayanad, Kerala, India.
Thamanna, P., and Prasanth, M. L. L. (2023). Comparative Review on Polyherbal and Monoherbal Cosmetic Formulations. i-manager's Journal on Chemical Sciences, 3(1), 32-35. https://doi.org/10.26634/jchem.3.1.19379

Abstract

This comparative review explores the characteristics and benefits of polyherbal and monoherbal cosmetic formulations. Formulations containing two or more herbs are called polyherbal formulations. Drug formulation in Ayurveda is based on the use of a single drug or more than one drug. A monoherbal formulation contains only one herb. The problem of polyherbal formulation occurs due to sources and manufacturing processes, patients, drug-herb interaction, toxicity, and improper manufacturing. Polyherbal formulations mean the use of more than one herb in a therapeutic preparation. In Ayurveda, multiple herbs are used in the treatment of illness.

Comparative Studies

Comparative Study of Herbal and Synthetic Cosmetics Available in the Market

Varsha James* , Lal Prasanth M. L.**
*-** Dr. Moopen's College of Pharmacy, Wayanad, Kerala, India.
James, V., and Prasanth, M. L. L. (2023). Comparative Study of Herbal and Synthetic Cosmetics Available in the Market. i-manager's Journal on Chemical Sciences, 3(1), 36-39. https://doi.org/10.26634/jchem.3.1.19366

Abstract

This paper presents a comparative study of herbal and synthetic cosmetics available in the market. The term "cosmetics" refers to compounds used externally to enhance appearance. It looks aesthetic and has a pleasant fragrance, which improves one's beauty and self-confidence. Herbal cosmetics are created by mixing one or more herbal substances with other cosmetic elements to treat a variety of skin conditions. Herbal cosmetics are supposed to be all-natural and free of any potentially dangerous synthetic chemicals that could harm the skin. Natural cosmetics are safer to use than other cosmetics. In synthetic cosmetics, a chemical reaction is used to create a synthetic substance called a compound. The importance of herbal cosmetics lies in the herbs utilized in them and their benefits over synthetic alternatives.