Aquagenic Urticaria: When Water Becomes Lethal
Transferosomes an Emerging Versatile Transformation in Research: An Advanced Review
Rubinstein - Taybi Syndrome: A Rare Genetic Disorder
Executing Quality Management Systems in Laboratory Testing and Biomedical Product Control
Assessment and Comparison of Respiratory Products Marketing Strategies in Community Pharmacies with Respect to Kerala
Assessment of Compliance of Respiratory Products Labels with 'The Drugs and Cosmetics Rules, 1945' Guidelines
Raising Concern of Substance Abuse among Adolescents in India: A Narrative Review
A Brief Review on Microspheres: A Promising Drug Carrier
Comparative Analysis of Ventilators and Oxygen Concentrator: Application, Advantages and Challenges
Aquagenic Urticaria: When Water Becomes Lethal
Executing Quality Management Systems in Laboratory Testing and Biomedical Product Control
Transferosomes an Emerging Versatile Transformation in Research: An Advanced Review
Rubinstein - Taybi Syndrome: A Rare Genetic Disorder
Raising Concern of Substance Abuse among Adolescents in India: A Narrative Review
Assessment and Comparison of Respiratory Products Marketing Strategies in Community Pharmacies with Respect to Kerala
Comparative Analysis of Ventilators and Oxygen Concentrator: Application, Advantages and Challenges
Raising Concern of Substance Abuse among Adolescents in India: A Narrative Review
Aquagenic Urticaria: When Water Becomes Lethal
Transferosomes an Emerging Versatile Transformation in Research: An Advanced Review
Water is ubiquitous in daily lives and generally regarded as harmless, yet for some patients, water is a source of great discomfort. Aquagenic Urticaria (AU) is a form of physical urticaria that occurs with cutaneous exposure to water, including sweat and tears. Patients present with characteristic 1–3 mm folliculocentric wheals with surrounding 1–3 cm erythematous flares within 20–30 minutes following skin contact with water. Aquagenic urticaria most commonly develops on the trunk and upper limbs. It is associated with pruritus and an uncomfortable prickling or burning sensation. With around 100 cases, the disease has received little to no attention from the scientific community. At this point, the pathophysiology of AU is not well known, however, it seems to be mediated both independently and in dependence on histamine. The water challenge test and a comprehensive clinical history are used to make the diagnosis. To rule out the possibility of other physical urticarias, certain patients might require additional testing. This paper focuses on the pathophysiology, diagnosis, and management of aquagenic urticaria. By raising awareness of this condition among health care providers, it may be possible to identify a larger group of patients to assist in further study.
The development of innovative approaches to deliver medications has been increasing, generating a growing interest in the dermatopharmaceutical field. For many therapies, transdermal drug administration in particular continues to be an appealing alternative method. It has advantages over traditional drug administration methods, which have drawn attention to them in recent years. Percutaneous medication administration is troublesome because the skin acts as a natural barrier and has a low penetration rate. Vesicular systems like liposomes, niosomes, elastic liposomes like ethosomes, and transferosomes have all been utilized to improve the transdermal dispersion of bioactives. Transferosomes seem to be a potential alternative among these. Hydrophilic actives, bigger molecules, peptides, proteins, and nucleic acids are few of the therapies that can be successfully delivered transdermally through transferosomes. The flexible structure for regulating capabilities and higher surface hydrophilicity to improve the solubility of transferosomes play a critical role in the transport of drugs and other solutes using hydration gradients, which act as a driving force to deliver the molecules into the skin. This results in increased overall permeation and controlled release of the drug into the skin layers. Transferosomes are said to have a number of applications, like the delivery of vaccines, proteins, anti-diabetic and anti-cancer drugs, anesthetics, and herbal drugs. They also have better patient compliance, improved bioavailability, and site-specific delivery and can serve as an emerging tool for transdermal delivery of almost all drugs and bioactives. This review provides an overview of the recent and relevant literature describing the emerging and versatile transformation of transferosomes in pharmaceutical research.
Rubinstein-Taybi Syndrome (RSTS) is a rare genetic condition caused by a mutation or deletion in the Cyclic AMP response element-binding protein coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13, or the EP300 gene located on chromosome 16. It affects an estimated 1 in 1,25,000 live births, and its characteristic features include growth delays, distinctive facial features, intellectual disability, and often angulated thumbs and toes. These patients are at increased risk of developing meningioma, other brain tumors, and leukemia. The syndrome presents with a diverse array of clinical features affecting multiple organ systems, including craniofacial abnormalities, cutaneous symptoms, cardiac defects, and developmental delays. Diagnosis typically involves molecular genetic testing alongside clinical evaluations, and management requires a multidisciplinary approach tailored to individual patient needs. Genetic counseling is essential due to the sporadic nature of RSTS, with most cases resulting from de novo mutations. The paper also discusses ongoing research into potential therapies and emphasizes the need for collaborative efforts to advance understanding, diagnosis, and management of RSTS.
This paper discusses the crucial significance of Quality Management Systems (QMS) in laboratory testing and the management of biomedical products, highlighting the importance of following industry guidelines like GLP, GMP, and GCP. This paper emphasizes that policies are crucial documents that outline primary organizational goals approved by management systems, and organizations need to synchronize their strategies with national policies. It challenges and provides future perspectives on establishing a successful QMS, emphasizing the importance of skilled employees, precise data processes, access to pertinent information, and error prevention to conserve time and resources. This paper recognizes the use of new techniques described in QMS guidelines to continuously improve organizations and companies, highlighting the consistent importance of tools such as the Sigma methodology for operational effectiveness. The importance of quality control systems in laboratory testing and managing biomedical products is emphasized in this paper. Adherence to GLP, GMP, and GCP regulations is essential for guaranteeing the safety, effectiveness, and dependability of scientific research and product development procedures. Highlighting accurate and provable results strengthens the importance of QMS in ensuring the reliability of scientific data and fostering continuous enhancement and compliance in the biomedical field.
Respiratory products are designated to support and improve respiratory function. They are primarily used to assist individuals who have difficulty in breathing due to various conditions, such as asthma, COPD or other respiratory disorders. Various marketing strategies are used for the promotion and sale of respiratory products. The purpose of this study is to assess and compare the marketing strategies of respiratory products in community pharmacies across 14 districts of Kerala. A semistructured questionnaire was prepared and distributed to 140 randomly selected community pharmacies in each district of Kerala and collected their responses within a period of 4 months. The study found that community pharmacies use marketing strategies such as discounts, advertisements, offerings, attractive labels, displays, etc. to promote respiratory products in Kerala. The community pharmacies use different marketing strategies to promote and increase the sale of respiratory products.
Respiratory disorders pose a significant health burden globally, necessitating the widespread use of respiratory products. Proper labeling of these products is essential for patient safety and regulatory compliance. This study aimed to assess the compliance of respiratory product labels with 'The Drugs and Cosmetics Rules, 1945' guidelines. A comprehensive analysis was conducted on the labels of various tablets, rotacaps, and respules collected from community pharmacies. Parameters such as drug name, official monographs, net weight, active ingredients, manufacturer details, batch number, manufacturing license number, and expiration date were evaluated. The study found varying levels of compliance across different parameters, highlighting areas for improvement. While certain aspects, like mentioning the drug name and manufacturer details, showed high compliance rates, others such as including caution and warning statements, exhibited lower adherence.
Substance abuse has been a global public health concern for decades. Various social, psychological, and health risks of substance abuse have been studied in detail. The objective of this narrative review is to understand and discuss the rising issue of substance abuse among adolescents in India and the measures to tackle this issue. A proper literature search and analysis, along with expert interviews, were conducted to understand the topic. The results showed a growing concern for various substances in Indian adolescents, especially alcohol, smoking, cannabis, and other synthetic products. Various factors, like genetics, family history, cultural factors, peer influence, and work culture, influence substance abuse in adolescents. Strict policy-making, the involvement of educational institutions, family counseling, and health system involvement are key to controlling this issue.
Improvements in unused drug delivery systems play a crucial role in pharmaceutical businesses. The drug delivery practice has been altered within the final decades, and numerous progressed advancements happened in later times. More up-to-date medical conveyance frameworks are generally affecting the current therapeutic hone. Modifications of a conventional or routine medicate conveyance into a modern sedate conveyance framework can completely change the bioavailability, security, and efficacy of the sedate, and they can also deliver progressed understanding compliance. The scope of the controlled medication conveyance framework is colossally impacting the pharmaceutical measurement shapes since it offers a wide range of items. Out of all controlled discharge items, microspheres are one of them because of their controlled discharge and maintained discharge properties. This paper centers on the different sorts of microspheres, their strategies of arrangement, and essential methods to assess their proficiency, with the most critical emphasis on the pharmaceutical application of microspheres by means of microspheres taken by different courses of framework such as verbal, transdermal, parenteral, etc.
This study compared and evaluated ventilators and oxygen concentrators, two essential pieces of medical equipment for respiratory care. Complex devices called ventilators help breathe by forcing oxygen-rich air into the lungs, on the other hand, oxygen concentrators take oxygen out of the surrounding air and increase its concentration. This paper explores their uses, benefits, drawbacks, and capabilities. Although they need maintenance and skill, ventilators offer precision breathing support that is essential in emergency and critical care situations. On the other hand, oxygen concentrators provide easier supplementary oxygen administration and are appropriate for both home use and chronic diseases, however, they are limited in cases of severe respiratory failure. This analysis makes educated decisions about the best respiratory care practices easier for researchers, legislators, and medical professionals.
