i-manager's Journal on Life Sciences (JLS)


Volume 2 Issue 1 January - April 2023

Research Paper

Formulation, Nutrient Analysis and Shelf Life Study of Watermelon, Pumpkin and Jamun Seeds Incorporated in Indian Snack Murukku

Jochebah Karen* , Angeline Esther Preethi**
*-** Department of Food and Nutrition, Rathnavel Subramaniam College of Arts and Science, Sulur, Coimbatore, India.
Karen, J., and Preethi, A. E. (2023). Formulation, Nutrient Analysis and Shelf Life Study of Watermelon, Pumpkin and Jamun Seeds Incorporated in Indian Snack Murukku. i-manager’s Journal on Life Sciences, 2(1), 1-9. https://doi.org/10.26634/jls.2.1.19422

Abstract

Nutritive snacks are supportive to people in their busy lifestyle. Seeds are used in major food resources like cereals and legumes since they are rich in protein, starch, oil, and many other micronutrients. The present study incorporates powdered watermelon seed, pumpkin seed, and jamun seed in Indian snack murukku to supply these nutrients to consumers, as these seeds are ignored by many even though they are found in enormous amounts. Besides murukku, the largely consumed savories are low in protein and mineral content. In the traditional Murukku recipe, instead of dhal, powdered seeds were added in 5 different proportions for 100 g of rice powder. Watermelon seed powder and pumpkin seed powder were added in 0%, 5%, 10%, 15%, and 20%, and jamun seed powder in 0%, 2%, 4%, 6%, and 8%. Jamun seeds were used in lesser quantities due to their sour taste. The standard and formulated products were analyzed for their sensory attributes using a 9-point hedonic scale. Nutritive values, protein, and energy levels of the products were analyzed using the Kjeldahl procedure and Bomb calorimeter, respectively. The iron content was analyzed using the AOAC method. Shelf life stability of the highest-scored product and the standard was done for a period of 30 days using microbial analysis and sensory analysis. A cost analysis was made to test and popularize the product among students aged 11 to 13 in RVS School, Sulur, Tamil Nadu, India. It was found that the 20% watermelon and pumpkin seedincorporated murukku scored the highest among the variations. In jamun seed incorporation, 2% addition scored the highest. The selected products had similar sensory attributes and shelf lives as the standard product at an affordable cost.

Review Paper

A Literature Review on Vaccine Hesitancy, Acceptance, and Anti-Vaccination Trends and Future Prospects for Public Health

Kashif Khan* , Uzma Bibi**, Shafaat Ullah***
*-*** Master of Science in Nursing, Aga Khan University, Karachi, Pakistan.
Khan, K., Bibi, U., and Ullah, S. (2023). A Literature Review on Vaccine Hesitancy, Acceptance, and Anti-Vaccination Trends and Future Prospects for Public Health. i-manager’s Journal on Life Sciences, 2(1), 10-19. https://doi.org/10.26634/jls.2.1.19330

Abstract

It is conceivable that not immunizing a child endangers both the child and others. If an outbreak occurs, the unvaccinated child is at risk. Smallpox, diphtheria, tetanus, pertussis, yellow fever, measles, and polio are some diseases that have been successfully controlled through vaccines. Vaccines have also played a crucial role in avoiding several illnesses. The Centers for Disease Control and Prevention (CDC) have recommended and demonstrated the safety and efficacy of these vaccinations. The number of doses required to provide optimal vaccination protection is a crucial component in determining the efficacy of a vaccine. Vaccines against infectious diseases have been shown to be successful throughout history, and several studies have demonstrated their safety and efficacy. However, the number of children who do not get vaccines is increasing. There are several reasons why parents choose not to vaccinate their children, including health concerns, financial restrictions, religious convictions, and a lack of faith in science and immunizations. This review begins with the methodology of conducting a literature search to obtain relevant data for the study. Google Scholar, PubMed, CINAHL, ScienceDirect, and the Centers for Disease Control and Prevention (CDC) were used as search databases. The entire review has three parts, such as vaccines from the past to the present, reasons for avoiding vaccines, and the problem of non-vaccination. An organized search strategy was employed to collect literature from PubMed, CINAHL, and Google Scholar. Boolean operators (AND/OR) were used to extract relevant publications. Publications were retrieved after applying certain filters, such as a time frame of ten years, full text availability, English language, and studies involving human subjects. For theoretical literature, the PMC library and Pakinet were searched. Subsequently, some studies were excluded based on irrelevance after reading the abstract and full article and checking for duplication. Most of the studies included in the review were conducted in Western countries, with a few from Asia and one from Pakistan. The literature search utilized the MESH typology.

Review Paper

Epilepsy and Genetics: A Review

Sibiya Dinesh* , Jebi Sudan**, Nikita Ojha***, Ekta Menghani****, Hardik Pathak*****, Rajendra Kumar Sureka******
*-***** Department of Biotechnology, JECRC University, Jaipur, Rajasthan, India.
****** Department of Neurology, Mahatma Gandhi Medical College, Jaipur, Rajasthan, India.
Dinesh, S., Sudan, J., Ojha, N., Menghani, E., Pathak, H., and Sureka, R. K. (2023). Epilepsy and Genetics: A Review. i-manager’s Journal on Life Sciences, 2(1), 20-30. https://doi.org/10.26634/jls.2.1.19314

Abstract

The term "epilepsy" refers to a wide range of conditions, the majority of which are triggered by interactions between many genes and environmental variables. Genetic epilepsies caused by single-gene alterations or specific structural chromosomal anomalies such as micro-deletions are much infrequent. These rare genetic forms of epilepsy often exhibit distinct clinical features and can provide valuable insights into the underlying biological mechanisms involved in seizure generation. The advancements in epilepsy genetics over the last ten to twenty years have opened up new avenues for diagnosis and treatment. For instance, many types of genetic epilepsies are discussed to show the multiple paths that might lead from genes to seizures. It has become evident that different genetic alterations can disrupt neuronal excitability, synaptic function, ion channel activity, or other critical biological processes, ultimately leading to seizure activity. Furthermore, the identification of specific genetic variants associated with drug response or treatment resistance has provided valuable insights into personalized therapeutic strategies for individuals with epilepsy.

Review Paper

Drugs: Stages of Drug Development and Methods to Control the High Usage of Drugs

Jyoti* , Bhumika Tuli**, Santosh Kumar***
* Department of Commerce, Chandigarh Group of Colleges, Landran, Mohali, Punjab, India.
** Department of Computer Science Engineering, Chandigarh Group of Colleges, Landran, Mohali, Punjab, India.
*** Department of Mechanical Engineering, Chandigarh Group of Colleges, Landran, Mohali, Punjab, India.
Jyoti, Tuli, B., and Kumar, S. (2023). Drugs: Stages of Drug Development and Methods to Control the High Usage of Drugs. i-manager’s Journal on Life Sciences, 2(1), 31-46. https://doi.org/10.26634/jls.2.1.19260

Abstract

Drug development is a complex and lengthy process that involves several stages, from the discovery of a potential drug molecule to its approval for marketing and distribution to patients. The drug development process typically takes several years and involves extensive testing and evaluation to ensure the safety and efficacy of the drug. All the possible effects based on drugs, such as addiction, drug abuse, alcohol use, drug development, drug discovery, and the use of drugs by students, are studied in this paper. This paper discusses how the rating of drug use changes over time and how to control it. This crucial information has been presented in this paper to regulate individual's use of drugs and reduce the world's susceptibility to drugs.

Review Paper

A Comprehensive Analysis of Covid-19: An Overview

Sona Scaria* , Neethu J.**, Dilip Krishnan K. K.***, Lal Prasanth M. L.****
* Dr. Moopen's College of Pharmacy, Kerala, India.
**-**** Department of Pharmacy Practice, Dr. Moopen's College of Pharmacy, Kerala, India.
Scaria, S., Neethu, J., Krishnan, K. K. D., and Prasanth, M. L. L. (2023). A Comprehensive Analysis of Covid-19: An Overview. i-manager’s Journal on Life Sciences, 2(1), 47-53. https://doi.org/10.26634/jls.2.1.19757

Abstract

The outbreak of the novel coronavirus disease 2019 (COVID-19) has emerged as one of the most significant global health crises in recent history. The novel SARS-CoV-2 coronavirus (CoV) is a previously undiscovered coronavirus. Since its initial identification in late 2019, COVID-19 has rapidly spread across continents, affecting millions of individuals and causing widespread disruptions to economies, healthcare systems, and daily life. It causes a severe acute respiratory syndrome. The coronavirus disease of 2019 is a dangerous, life-threatening illness caused by a beta-CoV of group 2B, known as COVID-19. This comprehensive analysis aims to provide an extensive overview of COVID-19, covering various aspects such as its origins, transmission, clinical manifestations, impact on public health, and global response strategies.