i-manager's Journal on Material Science (JMS)


Volume 12 Issue 1 April - June 2024

Research Paper

Addressing Bioprinting Challenges in Tissue Engineering

Sri Manoj Kumar N.* , Atheena Milagi Pandian S.**, Rashika Murugan***, Sudherson M.****
*-****Atheenapandian Private Limited, Chennai, Tamil Nadu, India.
Kumar, N. S. M., Pandian, S. A. M., Murugan, R., and Sudherson, M. (2024). Addressing Bioprinting Challenges in Tissue Engineering. i-manager’s Journal on Material Science, 12(1), 1-11. https://doi.org/10.26634/jms.12.1.20880

Abstract

This paper discusses the current challenges and potential solutions in the field of bioprinting tissues and organs. It highlights that most bioprinted tissues are small, composed of few cell types, lack vascular systems, and have limited functionality. This paper emphasizes the need to develop methods to obtain various functional cell types, create vascular systems for nutrient delivery, and enhance the size and capabilities of 3D-printed tissue structures. Additionally, it explores the advancements in nanorobots in the medical field, focusing on their unique properties and applications in various medical areas like cancer, cardiology, and neurology.

Research Paper

Synthesis of Zinc Oxide Nanoflower using Egg Shell Membrane as Template

Harminder Singh*
Department of Mechanical Engineering, Guru Nanak Dev University, Amritsar, Punjab, India.
Singh, H. (2024). Synthesis of Zinc Oxide Nanoflower using Egg Shell Membrane as Template. i-manager’s Journal on Material Science, 12(1), 12-16. https://doi.org/10.26634/jms.12.1.21024

Abstract

In this study, the nanocomposite of eggshell membrane is synthesized with ZnO by the chemical bath deposition (CBD) method, and eggshell membrane, which is used as a template, and decomposed. The end product obtained is nanoflowers of zinc oxide (ZnFs). The petals of nanoflowers obtained are of hexagonal cross-section similar to the unit cell structure of zinc oxide. The CBD parameters of temperature, reaction time, and solution pH were varied extensively during this study to obtain optimized parameters for the growth of ZnFs. The obtained nanoflower structure was analyzed using various characterization techniques of Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Spectroscopy (EDX), X-Ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR).

Research Paper

In Vitro and in Vivo Experiment of Antibacterial Silver Nanoparticle-Functionalized Bone Grafting Replacements

Atheena Milagi Pandian S.* , Rashika Murugan**, Mohammed Sahil S.***
*-*** Atheenapandian Private Limited, Chennai, Tamil Nadu, India.
Pandian, S. A. M., Murugan, R., and Sahil, S. M. (2024). In Vitro and in Vivo Experiment of Antibacterial Silver Nanoparticle-Functionalized Bone Grafting Replacements. i-manager’s Journal on Material Science, 12(1), 17-22. https://doi.org/10.26634/jms.12.1.20892

Abstract

Infection is a serious risk in transplant surgery and should be carefully considered while developing biomaterials. Silver nanoparticles (AgNPs) are gaining popularity due to their ability to enhance antibacterial capabilities against a wide range of bacterial types. This study sought to create two antibacterial bone regenerations by incorporating AgNPs into bovine bone particles (BBX) (Product 1) and a light cross-linked hydrogel GelMA (Product 2). Scanning electron microscopy was used to characterize the constructions. PrestoBlue™ was used to assess osteoblast and osteoclast metabolic activities on the creations. Optimized AgNP functionalized BBX and GelMA were tested in a rabbit cranial 6mm defect model to assess their regeneration ability. The presence of AgNPs appears to increase. In vitro, osteoblasts proliferated more than AgNP-free controls. It is found that a 100 μg dosage of AgNPs effectively suppresses bacteria while minimizing negative effects on bone cells. The rabbit model indicated that both BBX and GelMA hydrogels loaded with AgNPs were biocompatible, with no evidence of necrosis or inflammation. Grafts functionalized with AgNPs can defend against germs while also serving as a platform for bone cell adhesion.

Review Paper

Biocompatibility in Orthopedic Implants: Advancements and Challenges

Sri Manoj Kumar N.* , Atheena Milagi Pandian S.**, Rashika Murugan***, Sudherson M.****, Mohammad Sahil S.*****
*-***** Atheenapandian Private Limited, Chennai, Tamil Nadu, India.
Kumar, N. S. M., Pandian S. A. M., Murugan, R., Sudherson, M., and Sahil, S. M. (2024). Biocompatibility in Orthopedic Implants: Advancements and Challenges. i-manager’s Journal on Material Science, 12(1), 23-32. https://doi.org/10.26634/jms.12.1.20893

Abstract

For orthopedic implants, biocompatibility is essential to ensure that they integrate with biological systems without causing negative reactions or impairing tissue function. Orthopedic implants must be cellularly acceptable to interact with neighboring tissues, including muscle, cartilage, and bone. Implant materials should not cause cytotoxic reactions or inflammatory responses that might hinder healing or result in long-term inflammation. Progress in surface engineering and biomaterials science is discovering implants that work well with the body, benefiting patients in the long run. The biocompatibility of orthopedic implants, their interaction with surrounding tissues, and the potential for biological problems are all important aspects of their design and operation. Orthopedic implants must be successful and long-lasting to ensure biocompatibility, promote osseointegration (osteointegration), avoid biofilm development, and consider the patient's biological environment. This paper discusses biocompatibility in orthopedic implants, its advancements, and challenges.

Review Paper

Contemporary Approaches towards Emerging Visual Prosthesis Technologies

Rashika Murugan* , Atheena Milagi Pandian S.**, Mohammed Sahil S.***
*-*** Atheenapandian Private Limited, Tamil Nadu, India.
Murugan, R., Pandian, S. A. M., and Sahil, S. M. (2024). Contemporary Approaches towards Emerging Visual Prosthesis Technologies. i-manager’s Journal on Material Science, 12(1), 33-38. https://doi.org/10.26634/jms.12.1.21033

Abstract

Genetic conditions affecting eyesight can lead to vision loss due to a variety of disorders. These include traumatic events such as car accidents or blast injuries, as well as diseases like retinitis pigmentosa, glaucoma, and macular degeneration. After an accident or explosion, the remaining portion of the eye's nerve pathway may still function, allowing electrical devices to transmit significant images to the brain through a network of electrodes. Although current devices offer relatively limited vision, there has been significant progress since the initial proof of concept. Three devices have been approved for general use in various regions around the world, and several more are currently undergoing approval. The prospects for widespread adoption of device-based treatments for vision loss are promising. Much of the recent progress is due to advancements in semiconductors and biological compatibility. To create artificial vision and restore functionality, a camera or other image source electrically stimulates the residual healthy cells or tissues.