Harnessing the Power of Theranostic Materials for Combining Therapy and Diagnostics
Chemical Biology: What is Its Role in Drug Discovery
Antiviral Nutraceuticals from Pomegranate (Punica granatum) Juice
STUDY ON INHIBITION EFFICIENCY OF TRISODIUM CITRATE- Zn2+ SYSTEM OF MILD STEEL IN SEA WATER LINKED WITH BIOLOGICAL SYSTEM
INVESTIGATING THE EFFECT OF AUTOCLAVE STEAM STERILIZATION ON ANODIZED COLOUR IMPLANTS FOR COLOR FED ISSUE
Microwave Assisted Vacuum Drying of Thompson Seedless Grapes: Analysis of Characteristics And Kinetic Modelling
Adsorption and Characterization of Anisaldehyde as Corrosion Inhibitor for Aluminium Corrosion in Hydrochloric Acidic Environment
Yeast Recovery in Batch Ethanol Fermentation
The Repercussion of Leachate from Industries on Water Quality in Jeedimetla Village and its Surroundings, Medchal-Malkajgiri District, Telangana
Studies on Solubility Enhancement of Telmisartan by Adsorption Method
A Review on Cardiovascular Disease Treatment using Nano Drug Technology
INVESTIGATING THE EFFECT OF AUTOCLAVE STEAM STERILIZATION ON ANODIZED COLOUR IMPLANTS FOR COLOR FED ISSUE
Production of Modified Carboxymethyl Cellulose from Sawdust and Wheat Straw
Yeast Recovery in Batch Ethanol Fermentation
Modeling of Chromium (VI) Adsorption on Limonia Acidissima Hull Powder Using Artificial Neural Network (ANN) Approach
This study uses a minimalistic approach to determine the type and functional group of organic compounds. Employing microscale techniques and simple, cost-effective methodologies, it aims to make organic compound identification accessible and sustainable without compromising accuracy. The focus is on commonly used qualitative tests adapted for minimal reagent use and basic laboratory equipment. This approach benefits educational settings such as schools, colleges, and research centres.
Advancements in nanotechnology have ushered in nanosponges, biodegradable polyester structures with nanometersized cavities, designed for targeted drug delivery. Initially developed for topical applications, these nanosponges have evolved to be administered orally and intravenously. They exhibit a porous structure for controlled drug release, addressing issues like toxicity and poor bioavailability. Capable of carrying both hydrophilic and lipophilic drugs, nanosponges serve as versatile carriers for substances like enzymes, proteins, vaccines, and antibodies. Their characteristics include size and polarity control, crystalline forms, non-toxicity, stability in various conditions, suspension and regeneration capabilities, and a 3D structure for targeted capture and release. The composition involves a polymer, a cross-linking agent, and specific drug criteria. Advantages encompass targeted delivery, flavor masking, reduced side effects, water solubility, adjustable particle size, and easy commercial production. Disadvantages include limited encapsulation for larger molecules. The mechanism involves an open structure allowing prolonged release. Various types based on cyclodextrin offer unique properties. Factors affecting nanosponges include polymer nature, drug characteristics, complexation temperature, and degree of substitution. Preparation methods include solvent, ultrasound-assisted, melt, bubble electrospinning, and emulsion solvent diffusion methods. Comprehensive characterization includes drug entrapment efficiency, saturation state interaction, in vitro release studies, porosity measurement, and spectroscopic techniques. Applications span solubility enhancement, sustained delivery, oral and topical systems, protein delivery, protection from degradation, pollutant removal from water, cancer treatment, antiviral applications, enzyme immobilization, and modulation of drug release.
Cardiovascular Diseases (CVDs) pose a significant global health threat, with rising mortality rates attributed to factors like diabetes, obesity, and an aging population. This paper explores the evolving landscape of micro and nanoscale Drug Delivery Systems (DDSs) to enhance cardiovascular treatment efficacy. Various nanoagents, both organic (e.g., liposomes, dendrimers, polymeric nanoparticles) and inorganic (e.g., carbon nanotubes, silver nanoparticles, iron oxide nanoparticles), are classified and examined. The advantages, limitations, and preparation techniques of nanoagents are discussed, emphasizing their potential in targeted delivery, multifunctionality, minimal side effects, and enhanced efficiency. The anatomical details of the heart, layers of heart walls, and heart functions are presented for contextual understanding. The application of nanoagents in treating specific cardiovascular conditions, such as atherosclerosis, hypertension, myocardial infarction, and coronary artery disease, is thoroughly explored. Evaluation methods for nanoagents, including size and morphology analysis, surface charge determination, and molecular weight evaluation, are outlined. This paper concludes by emphasizing the promising role of nano-drug delivery systems in addressing CVD challenges, urging collaborative efforts for successful translational medicine implementation. Future research directions are proposed, highlighting the potential of peptides, antibodies, and selective nanodelivery systems in advancing cardiovascular care. Challenges like pharmaceutical scale-up, regulatory requirements, and patient preparation are acknowledged, underscoring the need for interdisciplinary collaboration to propel nanocardio medicine into clinical practice.
Drug repurposing is a powerful tool for future medicine, through the process of discovering new uses for existing drugs. Drug repurposing drastically cuts the time and expense involved in developing new medications by utilizing safety profiles and efficacy data that are currently available. In a diverse population of humans, people have unique sets of inherited or non-inherited genetic abnormalities that result in certain individuals responding less or not to all general treatments or drugs. Medicines that have been approved may not be suitable for a person because of the deficiency of a specific target. This situation leads to the requirement of personalized medicines. Reduced lack of efficacy drug repurposing approach has a significant role, which results in best medicine accompanied by low toxicity and high efficacy. This is achieved together with the advancement of next-generation sequencing technologies and personalized genomic studies can be conducted with an affirmative approach. Prospects include advancements in artificial intelligence, big data analytics and other technologies, focusing on rare diseases, combining repurposed drugs with other medications or novel drugs, and in the development of personalized medicines. Drug repurposing is exciting and fast-developing and possesses the potential to completely change the pharmaceutical industry's approach to the development of medications.
This paper explores the multifaceted role of AI in contemporary drug research, emphasizing its ability to analyze vast datasets, predict molecular interactions, and optimize clinical trials. AI's application extends beyond basic research, influencing preclinical studies, pharmaceutical design, clinical trials, and post-approval activities. It also plays a pivotal role in drug repurposing and the advancement of personalized medicine, where treatments are tailored to individual genetic profiles. By integrating AI into various stages of drug development, the industry has achieved increased efficiency, cost-effectiveness, and accuracy. This paper also highlights the regulatory challenges and opportunities posed by AI, stressing the need for a flexible regulatory framework to balance innovation with patient safety. As AI continues to evolve, its impact on the pharmaceutical industry is expected to grow, driving further advancements in drug research and ultimately leading to improved patient outcomes and a more efficient healthcare system.
