Anticancer Natural Products:A Systematic Review and Meta-study
Neuroplasticity: The Brain's Capacity for Adjustment and Transformation
Optimizing Patient Safety and Dose Reduction Strategies in Abdominal, Chest, and Skull CT Imaging: A Comprehensive Analysis of Effective Dose Quantification
Skin Grafting for Burn Injuries - Tilapia Fish Skin
Somatic Nuclear Transfer (Embryo Stem Cells) in Organ Printing
Survey Based on the Role of Advertisements in Buying Behaviour of Nutraceuticals
Perceived Impact of Sexuality Education towards the Occurrence of Teenage Pregnancy among Senior Secondary School Students in Ogbomosho North, Oyo State, Nigeria
Aquagenic Urticaria: When Water Becomes Lethal
Executing Quality Management Systems in Laboratory Testing and Biomedical Product Control
Transferosomes an Emerging Versatile Transformation in Research: An Advanced Review
Raising Concern of Substance Abuse among Adolescents in India: A Narrative Review
Rubinstein - Taybi Syndrome: A Rare Genetic Disorder
Assessment and Comparison of Respiratory Products Marketing Strategies in Community Pharmacies with Respect to Kerala
Comparative Analysis of Ventilators and Oxygen Concentrator: Application, Advantages and Challenges
Raising Concern of Substance Abuse among Adolescents in India: A Narrative Review
Aquagenic Urticaria: When Water Becomes Lethal
Transferosomes an Emerging Versatile Transformation in Research: An Advanced Review
Natural anticancer compounds, derived from plants, marine organisms, fungi, and microorganisms, exhibit significant therapeutic potential in oncology. These bioactive compounds play a crucial role in inhibiting tumor growth, promoting apoptosis, and suppressing malignancy through diverse mechanisms. This review explores the various classes of natural anticancer agents, including polyphenols, alkaloids, terpenoids, and peptides, highlighting their mechanisms of action and clinical relevance. Key examples include resveratrol, curcumin, paclitaxel, and epigallocatechin gallate, along with marine-derived compounds like bryostatin-1 and discodermolide, which have demonstrated promising anticancer properties. Despite their potential, challenges such as bioavailability, toxicity, and formulation hinder their clinical translation. However, advancements in drug delivery systems and combination therapies present promising strategies to overcome these limitations and enhance therapeutic efficacy. Further research is essential to optimize pharmacokinetic properties, understand molecular interactions, and explore synergistic combinations for developing more effective and safer anticancer treatments.
Neuroplasticity refers to the brain's remarkable ability to reorganize itself by forming new neural connections, playing a crucial role in learning, memory, and recovery from brain injuries. This study investigates the mechanisms of synaptic plasticity, specifically focusing on the biochemical processes within synapses and neurons that contribute to brain changes. Through an exploration of long-term potentiation (LTP) and long-term depression (LTD), this research highlights how synaptic strength can be modified. By understanding the relationship between synaptic plasticity and cognitive functions such as learning and memory, the study provides new insights into the dynamic and adaptive nature of the brain. These findings have significant implications for therapies targeting brain recovery and cognitive enhancement.
CT imaging plays a crucial role in medical diagnostics, but it comes with radiation exposure risks. Diagnostic Reference Levels (DRLs) are essential tools for optimizing imaging protocols and ensuring patient safety. This study evaluates the effective dose (ED) from abdominal, chest, and skull CT exams using advanced MDCT systems across ten radiological centers in southern Nigeria, with the primary objective of assessing the alignment of local imaging protocols with international reference standards to optimize patient safety and reduce radiation exposure. The study quantifies the effective doses for these CT examinations, compares them with national and local DRLs, and analyzes adherence to international benchmarks to identify opportunities for dose reduction and safety improvements. A total of 2,828 CT scans, including abdominal, chest, and skull imaging, were analyzed from MDCT scanners, with dose descriptors extracted from image dose reports to calculate the ED using established dose-length product conversion coefficients. The calculated ED values were compared with national and local DRLs as well as internationally published reference benchmarks. The comparative analysis revealed significant variations in ED values across different types of CT exams, highlighting areas where dose optimization is possible. The findings suggest that some centers need to adjust their protocols to better align with best practices and improve patient safety. This study provides valuable insights into radiation dose levels in southern Nigeria, offering recommendations for protocol adjustments and enhanced patient safety while serving as a guide for improving local imaging practices, reducing radiation exposure, and ensuring better clinical outcomes.
Burns are a significant global health issue, with the World Health Organization (WHO) reporting nearly 180,000 deaths annually due to burns. In India alone, nearly 1 million people suffer from moderate to severe burns each year. To address this, skin grafting using tilapia fish skin has emerged as a promising solution. This study provides an overview of the technique and its outcomes in burn injury treatment. Skin grafting is a medical procedure that involves harvesting healthy skin to replace damaged tissue, considering factors such as anti-inflammatory properties, durability, and aesthetic matching. Burns can severely damage human skin, resulting in prolonged healing times and potential scarring. Tilapia fish skin grafting is an innovative clinical approach that has been increasingly used to treat burn injuries. This method has shown promising clinical results, offering better outcomes in burn injury recovery.
In the modern era, individuals face various health challenges due to congenital conditions and lifestyle habits that can lead to malfunctioning or failure of internal organs. While medications can support organ function, they are not a permanent solution and come with long development times, high costs, and potential side effects. As organ failure, particularly kidney failure, continues to rise, the need for effective treatments, such as organ transplantation, becomes more critical. However, the limited availability of donors, the high genetic rejection rates, and the time-consuming nature of organ transplantation pose significant challenges. To address these issues, regenerative medicine and 3D bioprinting have emerged as promising solutions. This paper explores the cultivation and synthesis of cells for use in organ printing, focusing on the somatic nuclear transfer (SCNT) method, which offers advantages over traditional cell culture techniques. Unlike conventional methods, SCNT enables limitless cultivation of target cells, reduces immune rejection, and increases cell viability and rheological properties. This paper also discusses the SCNT process and the preparation of bio-inks for 3D organ printing, aiming to provide a viable alternative to organ transplantation.
This study investigates the impact of marketing on consumer purchasing decisions in the nutraceutical sector, particularly for functional foods and nutritional supplements. Through a survey, the research examines how various advertising strategies, including social media campaigns, digital marketing, celebrity endorsements, and health-related claims, influence consumer perceptions and buying behavior. The study focuses on demographic factors such as age, gender, income, and health awareness. Key findings suggest that trust in the advertised product, the credibility of the source, and the emotional appeal of health benefits play significant roles in shaping purchasing decisions. Additionally, the research highlights the growing importance of transparency and scientific evidence in nutraceutical promotions, as consumers increasingly value data-supported health claims. The study offers insights into effective advertising strategies for the nutraceutical industry to enhance consumer engagement and encourage informed purchasing decisions.
Teenage pregnancy, which occurs among adolescents under 20, has far-reaching effects on maternal and child health, society, and the economy. It is linked to unprotected sexual intercourse, sexual coercion, peer pressure, and poverty, making it a global health issue that can be prevented. This study aimed to evaluate the perceived impact of sex education on the occurrence of teenage pregnancy among students in selected secondary schools in Ogbomoso North Local Government. A descriptive design was adopted, and data were collected using a self-structured questionnaire with informed consent. The findings revealed that 75% of respondents were introduced to sexuality education primarily through social media. Additionally, 51% believed that sex education increases knowledge of sexual and reproductive health and rights. Overall, 60% of respondents had a positive perception of sex education, while 40% had a poor perception. Three null hypotheses were tested, and the results showed no significant relationship between the age of the respondents and their awareness of sex education. Based on the findings, it is recommended that sensitization programs be implemented by government agencies and private stakeholders to educate young people on the importance of comprehensive sex education in preventing teenage pregnancy.
