Process Intensification for Separation of Carboxylic Acids from Fermentation Broths using Reactive Extraction

Sushil Kumar*
*Lecturer,Chemical Engineering Department ,Bits Pilani.
**Dean,Educational Hardware Division &Processor ,Chemical Engineering Department ,Bits Pilani.(Rajasthan),India.
Periodicity:February - April'2008
DOI : https://doi.org/10.26634/jfet.3.3.643

Abstract

The potential role of a new energy efficient fermentation technology has been receiving growing attention in past 4 decades. Carboxylic acids such as propionic acid, lactic acid, citric acid, tartaric acid, itaconic acid, butyric acid and nicotinic acid etc. have been used as the most efficient fermentation chemicals. This paper presents a state-of-art review on the development of the separation techniques for carboxylic acids from fermentation broths. This paper mainly focuses on reactive extraction that is found to be a promising alternative to the conventional recovery processes in terms of intensifying the process.

Keywords

Carboxylic acids, Fermentation, Separation Processes, Process intensification, Reactive Extraction.

How to Cite this Article?

Sushil Kumar and B.V. Babu (2008). Process Intensification for Separation of Carboxylic Acids from Fermentation Broths using Reactive Extraction. i-manager’s Journal on Future Engineering and Technology, 3(3), 21-28. https://doi.org/10.26634/jfet.3.3.643

References

[1]. Honda, H., Toyama, Y., Takahashi, H., Nakazeko, T., Kobayashi, T., Effective lactic acid production by two- stage extractive fermentation. J. Ferment. Bioeng. 1995, 79:589-593.
[2]. Evans, R J., Wang, H. Y., Effects of extractive fermentation on butyric acid production by Clostridium acetobutylicum. Appl. Microbiol. Biotechnol. 1990, 32: 393- 397.
[3]. Hatzinikolaou, D. G., Wang, H. Y., Extractive fermentation systems for organic acids production. Can. J. Chem. Eng. 1992,70:543-552.
[4]. Yabannavar, V. M., Wang, D. I. C., Extractive fermentation for lactic acid production. Biotechnol. Bioeng. 1991,37:1095-1100.
[5]. Hartl, J. and Marr, R., Extraction Processes forBioproduct Separation, Separ. Sci. Techno/.,28, 805 (1993).
[6]. Anonymous. Chem. Mark. Rep. 1994, Dec 12- 30.
[7]. Chemical Economics Handbook; SRI International-. Menlo Park, CA, 2003.
[8]. Ullmann Encyclopedia of Industrial Chemistry. 1995, 5thEd.A27,581.
[9]. Galaction, A.I. and Cas^caval, D., Secondary Metabolites with Pharmaceutical, Cosmetic and Food Applications; Venus: Iasi, 2006, Romania.
[10]. Atkinson B. and Mavituna F., Biochemical Engineering and Biotechnology Handbook (The Nature Press-MacMillan, London, 1983).
[11]. Category: Carboxylic Acids, Wikipedia, free encyclopedia (database on Internet). [Updated December 3, 2007], Available from: http ://en.wikipedia. org/wiki/Category: Carboxylic_acids.
[12]. Hauer, E. and Marr, R., Liquid Extraction in Biotechnology. International Chemical Engineering. 1994,34(2): 178-187.
[13]. Wardell, J. M. and King, C. J., Solvent equilibria for extraction of carboxylic acids from water. Journal of Chemical and Engineering Data. 1978,23:144-148.
[14]. Baniel, A. M., Process for the extraction of organic acids from aqueous solution. EP 0049429,1982.
[15]. Boyaval, R, Corre, C. and Terre, S., Continuous lactic acid fermentation with concentrated product recovery by ultra-filtration and electrodialysis. Biotechnol. Let. 1987,9 (3): 207-212.
[16]. Timmer, J. K. M., Kromkamp, J. and Robbertsen, T., Lactic acid separation from fermentation broth by reverse osmosis and nanofiltration. J. Membr. Sci. 1994, 92: 185-197.
[17]. Hongo, M., Nomura. Y., Iwahara, M., Appl. Environ. Microbiol. 1986,52 (2): 314.
[18]. Nomura, Y., Iwahara, M., Hongo, M., Lactic acid production by electrodialysis fermentation using immobilized growing cells. Biotechnol. Bioeng. 1987, 30: 788- 793.
[19], Lee, E. G., Moon, S., Chang, Y. K.,Yoo, I., Chang, H. N., Lactic acid recovery using two-stage electrodialysis and its modeling. J. Membr. Sci. 1998,145:53-66.
[20]. Cockrem, M. C. M., Johnson, R D., Recovery of lactate and lactic acid from fermentation broth, 1991, U.S. Patent5,210,296.
[21], Sirman, I, Pyle, D. L., Grandison, A. S., Extraction of organic acids using a supported liquid membrane. Biochemical Society Transactions. 1991,19 (3): 274-279.
[22]. Cao, X., Yun, H. S., Koo, Y.M., Recovery of lactic acid by anion- exchange resin Amberlite IRA-400. Blochem. Eng. J. 2002,11:189-196.
[23]. Dai, Y., King, J., Selectivity between lactic acid and glucose during recovery of lactic acid with basic extractants and polymeric sorbents. Ind. Eng. andChem. Res. 1996,35:1215-1224.
[24]. Pazouki, M., Panda, T., Recovery of citric acid - a review. BloprocessEng. 1998,19:435-439.
[25]. Kawabata, N., Yasuda, S., Yamazaki, T., US patent 4323702,1982.
[26]. Chen, C.C. and Ju, L.K., Appl. Microbiol. Biotechnol. 2002,59:170.
[27], Wasewar K. L., Separation of Lactic Acid: Recent Advances. Chem. Blochem. Eng. Q. 2005, 19 (2): 159-172.
[28]. Freeman, A., J. M. Woodley, and M. D. Lilly., "In Situ Product Removal as Tool for Bioprocessing", Biotechnology. 1993,11,1007.
[29]. Jaquet, A., L. Quan, I. W. Marison, and U. von Stockar. Factors Influencing the Potential Use of Aliquot 336 for the In Situ Extraction of Carboxylic Acids from Cultures of Pseudomonas Putlda, J. Biotechnol. 1999, 68:185.
[30]. Jaquet, A., L. Quan, H.-R Meyer and U. von Stockar. Choice of a Method for In Situ Recovery of 3-Pyridyl-Acetic Acid formed by Biotransformation with Pseudomonas Oleo'orans, Chimia, 1996,50:427.
[31]. Weilnhammer C., Blass E., Continuous Fermentation with Product Recovery by in situ Extraction. Chem. Eng. andTechnol. 1994,17:365-373.
[32]. Wennersten, R., Extraction of Carboxylic acid from fermentation broth in using solution of tertiary amine, J. Chem. Technol. Biotechnol. 1983,33B: 85-94,
[33]. Cascaval D. and Galaction A. I., New Separation Techniques on Bioseparations 1. Reactive Extraction, Chem. Ind. 2004,58 (9): 375-386.
[34]. Cascaval D., Oniscu C., Dumitru I.F. and Galaction A.I., New Separation Techniques in Biotechnology, Roum. Biotechnol. Lett. 2001,6(3): 207-232
[35]. Wasewar K.L., Yawalkar A., Moulijn J., Pangarkar V.G., Fermentation of Glucose to Lactic acid Coupled with Reactive Extraction: A Review. Ind. Eng. and Chem. Res. 2004,43:5969-5982.
[36]. Kahya E., Bayraktar E., Mehmeto G. U., Optimization of Process Parameters for Reactive Lactic Acid Extraction. Turk. J. Chem. 2001,25:223-230.
[37]. Yang, S., White, S. A., Hsu, S., Extraction of carboxylic acids with Tertiary and Quaternary Amines: Effect of pH. Ind. Eng. Chem. Res., 1991,30,1335-1342.
[38]. Kertes, A.S. and King, C., Extraction Chemistry of Fermentation product Carboxylic Acids. Biotechnol. S/oeng. 1986,28:269-282.
[39]. Schugeri K., Solvent Extraction in Biotechnology, Springer-Verlag, Berlin, 1994.
[40]. Tamada, J. A., Kertes, A. S. and King, C. J., Extraction of carboxylic acids with amine extractants. 1. Equilibria and Law of Mass Action Modeling. Ind. Eng. Chem. Res., 1990,29 (7): 1319-1326.
[41 ]. Tamada, J. A. and King, C. J. Extraction of carboxylic acids with amine extractants. 2, Chemical Interactions and Interpretation of Data. Ind. Eng. Chem. Res., 1990, 29 (7): 1327-1333.
[42]. Tamada, J. A. and King, C. J. Extraction of carboxylic acids with amine extractants. 3. Effect of Temperature, Water Coextraction and Process Considerations. Ind. Eng. Chem. Res., 1990,29:1334-1338.
[43]. Hong Y. K. and Hong W. H., Reactive extraction of lactic acid with mixed tertiary amine extractants. Biotechnol. Techniques. 1999,13:915-918.
[44]. Wasewar K. L., Heesink A.B.M., Versteeg G.F., Pangarkar V.G., Reactive Extraction of Lactic acid using Alamine 336 in MIBK: Equilibria and Kinetic. J. Blotechnol. 2002,97:59-68.
[45]. Malmary G., Albet J., Putranto A.M.H. And Molinier J., Recovery of carboxylic acids from aqueous solutions by liquid-liquid Extraction with a triisooctylamine diluent system. Brazil. J. Che. Eng. 2001,18 (4): 441-447.
[46]. Mariya M., Joel A., Jacques M. and George K., Specific Influence of the Modifier (1-Decanol) on the Extraction of Tartaric Acid by Different Extractants. Ind. Eng. Chem. Res., 2005,44:6534-6538.
[47], Poposka, F.A., Nikolovski, K. and Tomovska, R., Kinetics, Mechanism and Mathematical Modeling of Extraction of Citric Acid with lsodecanol/n-para_ns Solution of trioctylamine. Che. Eng. Sci. 1998, 53 (18): 3227-3237.
[48]. Matsumoto, M., Otono, T., Kondo, K., Synergistic extraction of organic acids with tri-n-octylamine and tri-n- butylphosphate. Sep. Purif. Technol. 2001,24:337- 342.
[49]. Hong Y. K. and Hong W. H, Influence of Chain Length of Tertiary Amines on Extractability and Chemical Interactions in Reactive Extraction of Succinic Acid, KoreanJ. Chem. Eng. 2004,21 (2): 488-493.
[50]. Cascaval D., Onisco C. and Hung J. J., Ind. Chem. 1997,25:245.
[51]. Cascaval D., Onisco C. and Hung J. J., Ind. Chem. 2000,28:99.
[52]. Wasewar K. L. and Pangarkar V.G., Intensification of Propionic Acid Production by Reactive Extraction: Effect of Diluents on Equilibrium, Chem. Biochem. Eng. Q. 2006, 20 (3): 325-331.
[53]. HanoT., Matsumoto M., OhtakeT., Sasaki K., Hori F. and Kawano Y., Extraction equlibria of organic acids with tri-n-octylphosphine oxide. J. Chem. Eng. Jap. 1990, 23: 734-738.
[54]. Al-Mudhaf H.F., Hegazi M.F. and Abu-Shady A.I., Partition data of acetic acid between aqueous NaCI solutions and trioctylphosphine oxide in cyclohexane diluent. Sep. Pur. Technol. 2002,27:41 -50
[55]. Cai, W., Zhu, S. and Piao X., Extraction equilibria of formic and acetic acids from aqueous solution by phosphate-containing extractants. J. Chem. Eng. Data. 2001,46:1472-1475.
[56]. WangY., Li Y., Li Y., Wang J., LiZ. and DaiY., Extraction equilibria of monocarboxylic acids with trialkylphosphineoxide. J. Chem. Eng. Data. 2001, 46: 831-837.
[57]. Wisniewski M. and Pierzchalska M., Recovery of carboxylic acids C1C3 with organophosphine oxide solvating extractants. J. Chem. Technol. Biotechnol. 2005,80:1425- 1430.
[58]. Kumar S., Vibhuti, Babu B. V. and Wasewer K 1., Intensification of Recovery of nicotinic acid using Reactive extraction: Equilibrium Study, Proceedings of International Symposium & 59th Annual Session of IIChE (CHEMCON-2006), Bharuch, December 27-30,2006.
[59]. Kumar S., Babu B .V. and Wasewer K. L., Recovery of propionic acid using reactive extraction. Proceedings of International Symposium & 59th Annual Session of IIChE [CHEMCON-2006], Bharuch, December 27-30,2006.
[60]. Cascaval D. and Galaction A. I., Blaga A. C. and Camarut M., Comparative Study on Reactive Extraction of Nicotinic Acid with Amberlite LA-2 and D2EHPA, Sep. Sci. Technol. 2007,42:113,.
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