Mistakes are an indispensable portion of human life. Implementation of medical orders is an imperative part of the the rapeutic process and patient care. It is also the key element of nursing act and has a significant role in patient wellbeing particularly in emergency situation. Errors while administering medications can considerably affect patient safety and treatment expenditures and result in threats for patients and their families. The objective of the study was to determine the effectiveness of Self-Instructional Module (SIM) on knowledge regarding emergency drugs among health workers in selected PHC's of Udupi district. A quantitative evaluation approach with a pre-experimental; one group pre-test – posttest design was used. Sixty subjects were drawn by using purposive sampling technique. Pre-test knowledge was checked by using a structured knowledge questionnaire on Emergency drugs. Post-test knowledge assessment was done ten days after the intervention. The mean pre-test knowledge score was 10.3 ±2.69 and the mean post- test knowledge score was 22.85 ±2.48. Paired t-test was done to find the effectiveness of Self-Instructional Module (SIM) on emergency drugs and it was found there was a significant enhancement of knowledge (t=19.74, P<0.05). The present study results showed that self-instructional module on emergency drugs was effective in terms of improving the knowledge among health workers of primary health centres. The present study also supports the necessity for additional pharmacology training for health workers in clinical settings, concentrating on common medications they commonly administer, about the indications, route of administration, side effects, etc.