Negative pressure is one of the metastable states of liquids at which it can be extended up to a certain limit without a gap of continuity. There are numerous experimental studies where a negative pressure up to 40 MPa has been obtained at laboratory conditions. However, these results of the experimental works were not practically implemented, as real liquids both in the nature and the technological processes contain impurities. Under certain kinetic and hydrodynamic conditions the waves of negative pressure in real liquids (crude oil, water, and water-based solutions) were observed. The wave of negative pressure is a turned soliton wave with one negative hump. It is a conservative wave, which maintains its shape and dimensions, and travels long distances with the speed of sound. An advanced technology of generation of the negative pressure wave in real systems allowed creating completely new energy saving technology. This technology based on negative pressure phenomenon has been already used for increasing oil production efficiency during various oil well operations, cleaning of oil well bore, and pipelines from various accumulations. It is shown that a new technology has a lot of potentials for bottom-hole cleaning operations, oil recovery enhancement, pipeline transportation, gas-lift operation etc.