The challenges teachers face everyday in effectively teaching ALL students along a pre-determined path, usually with pre-determined curricula, towards a goal of adequate yearly progress is overwhelming to say the least. Classrooms are comprised of more and more diverse students in terms of ability, background and experiences, learning preferences, and instructional needs. In order to effectively facilitate learning experiences for their diverse classrooms, teachers must differentiate their daily instruction. This article offers four broad categories of strategies to consider when designing and differentiating instruction to better facilitate learning for all students: (a) instructional organization, (b) instructional delivery and methods, (c) student progress monitoring, and (d) organizational supports. Additionally, implications for practicing teachers and preservice teachers are highlighted.