This paper is part two of the article entitled, “Dynamic Neuroscientific Systemology: Using Tri–Squared Meta–Analysis and Innovative Instructional Design to Develop a Novel Distance Education Model for the Systemic Creation of Engaging Online Learning Environments.” published in the July–September 2015 issue of i-manager’s Journal of Educational Technology. The aim of this paper is to introduce three novel problems–solving conceptual solutions which are: (1)  Neuro-Holistic Learning as an; (2) “Integrated Kinesthetic Approach to Cognitive Learning ”using a (3) “Collaborative  Interactive Thought Exchange ” as a dialogue and discussion procedure. The purpose of this original and novel st instructional methodology is to conceptually addresses the four main challenges faced by 21 century African American high school and college students, particularly African American males, who are attempting to succeed in life and in their future professional careers. As an instructional methodology, Neuro-Holistic Learning provides an active solution that addresses the needs of Historically Black Colleges and Universities (HBCUs) who are actively seeking novel methods to aid in the achievement of their respective academic goals, increase student retention, meet their institutional graduation objectives. The results of this dynamic and engaging approach to learning determinedly responds to HBCU high standards of academic excellence and collaborative goals to produce dynamic global citizens and actively responsive alumni.