Hepatitis C virus (HCV) is one of the most widespread infectious diseases. It is becoming a major public health problem of developing countries, including Pakistan that has the second highest prevalence rate of HCV ranging from 4.5% to 8% (World Health Organization).There are various determinants that are contributing to the rising trend of hepatitis C in Pakistan. The most prevalent cause includes reuse of syringes and needles, usage of unsterile equipment, especially by local dentists and barbers, multiple sex partners, unscreened blood transfusions, unavailability of proper health care delivery system, and lack of awareness. The general public is either infected with the virus or they are most vulnerable of contracting it, due to several malpractices and misperceptions. Therefore, there is an urgent need to take preventive measures at primary, secondary and tertiary level to tackle this widespread disease.