In the analysis and design of multi-storey buildings, it is generally assumed that underlying soil is perfectly rigid and bounded to the structure. This assumption leads to gross error in assessment of the overall response under dynamic loadings. The Indian Code specifically gives no clear guidelines for design of high rise buildings in regions of soft soil. Hence it is very important to evaluate the extent of effect of such assumptions on the overall design. This paper deals with structural response of building under dynamic soil-structure interaction. Analysis for fairly stiff base soil has been carried out, using a powerful Finite Element Method (FEM) software package ANSYS v14.5. Results corresponding to fixed base and with consideration of soil-structure interaction have been compared and lead to some very important conclusions regarding time period, deflection and acceleration responses.