Hepatitis C Virus (HCV) infection has become a global public health concern and demanding high priority efforts for primary prevention, treatment, and awareness campaigns among the public. The determinants of HCV are common in developed and developing countries; the major source of HCV infection is unprotected sexual contact, infected blood transfusion, sharing of infected needles among the drug users, and perinatal transmission. Majority of the population is not aware about their health status whether they are infected with this virus or not. So, they unknowingly transmit this infection to others as well. Unfortunately, HCV infection vaccine has not been found in the world; extensive measures have been required to control this problem at national level for its prevention because its treatment is very expensive and it contributes a huge burden on the country's economy. Community stakeholders and health care providers can play an important role in awareness campaigns and early screening and detection of the diseases especially among the high-risk population.