This paper is an endeavor to develop a customised and computerized matrix of Quality Function Deployment paradigm (QFD) that has been applied in industry, with the aim of probing quality assurance and enhancement in Universities. Results of testing the new matrix proved that, it is efficient and time-saving while compared with a detailed field study conducted at Philadelphia University, Jordan by the Jordan Accreditation Council. Challenges facing the application of the diverse relevant methodologies are mainly the scarcity of communication technologies and lack of physical and financial resources. This paper supports the adoption of the customized paradigm, to point out the following such as, Hybrid edutainment should be implemented; offices of quality management should be given a role in decision-making in Universities; awareness programs regarding the methods of quality assurance and enhancement should be organized, the culture of collaboration and interactivity among faculty members should be supported; and formation of regional networks of quality management should be advocated.