This study examines the role of higher education institutions (HEIs) in fostering entrepreneurial innovation and sustainable practices and how these initiatives impact occupational stress among women teachers. Using an empirical approach, the research collects primary data from women educators across selected colleges and universities. The study applies a structured questionnaire measuring entrepreneurial support, sustainability initiatives, and occupational stress levels. Statistical tools, including correlation and regression analysis, are employed to determine the relationships between institutional practices and teacher stress. The findings aim to offer practical suggestions for policymakers and educational administrators to design interventions that enhance both institutional innovation and teacher well-being.