Aging is an important part of all human life. It is the last stage of human life and they become weaker on physical perspective as well as more sensitive and emotional on psychological perspective. The aim of this reminiscence therapy is to improve the self esteem and mental well-being of senior citizens. The aim of the study was to evaluate the effectiveness of reminiscence therapy on self esteem and mental well-being among senior citizens residing in selected convalescent home at Kanniyakumari district Tamilnadu. The design used in this study is quasi experimental with pretest posttest control group design. The study is conducted in St. Joseph old age home and Anbaham old age home. The tools used were Rosenberg self esteem and the Warwick Edinburgh mental well-being scale. The investigator given reminiscence therapy is effective in improve the self esteem and mental well-being among senior citizens residing in selected convalescent home.