Exploring the Stability and Synthetic Applications of Chiral Methylmetals in Asymmetric Organic Reactions

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Periodicity:September - December'2024

Abstract

Chiral methylmetals play a crucial role in modern synthetic chemistry, particularly in asymmetric synthesis. This paper explores the configurational stability of organolithium compounds and their applications in stereoselective reactions. We discuss the configurational retention of chiral methyllithium derivatives and their transformations via Stille coupling. Experimental observations highlight the stability of various chiral metal-methyl complexes under different reaction conditions. Comparisons with existing literature suggest that these complexes are potential candidates for selective organic transformations. The study contributes to the understanding of organolithium behavior and extends its applicability in industrial and pharmaceutical chemistry.

Keywords

Chiral organolithium, Configurational stability, Stille coupling, Asymmetric synthesis, Organometallics

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