i-manager Publications

Efficient Synthesis of Losartan Potassium: An Improved Two-Step Method

Prashant Rajendra Sonawane*

Savitribai Phule Pune University, Maharashtra, India.

Periodicity:September - December'2024
DOI : https://doi.org/10.26634/jchem.14.3.21569

Abstract

A highly effective and high-yield synthetic approach for producing Losartan Potassium in two steps is presented. The method begins with Trityl Losartan, which undergoes a reaction with Potassium Tertiary Butoxide in Tetrahydrofuran to yield Losartan Potassium. Subsequently, purification using Isopropyl alcohol results in the production of pure Losartan Potassium.

Keywords

Synthesis, Losartan Potassium, High-Yielding.

How to Cite this Article?

Sonawane, P. R. (2024). Efficient Synthesis of Losartan Potassium: An Improved Two-Step Method. i-manager’s Journal on Chemical Sciences, 4(3), 43-47. https://doi.org/10.26634/jchem.14.3.21569

References

[1]. Chen, Z., Guo, Y., Niu, H., Wang, J., Li, J., Li, C., & Qiao, R. (2022). Development of a new synthetic route of the key intermediate of Irbesartan. Organic Process Research & Development, 26(8), 2438-2446.

[2]. Deprez, P., & Vevert, J. P. (1996). Synthesis of difluoromethylthio imidazole from methylthio imidazole. Journal of Fluorine Chemistry, 80(2), 159-162.

[3]. Fu, J. (2025). Angiotensin II receptor antagonists for treatment of hypertension: The discovery of losartan and its analogs. In Medicinal Chemistry and Drug Development (pp. 109-139). Elsevier.

[4]. Madasu, S. B., Vekariya, N. A., Koteswaramma, C., Islam, A., Sanasi, P. D., & Korupolu, R. B. (2012). An efficient, commercially viable, and safe process for preparation of losartan potassium, an angiotensin II receptor antagonist. Organic Process Research & Development, 16(12), 2025-2030.

[5]. Mavromoustakos, T., Moutevelis-Minakakis, P., Kokotos, C. G., Kontogianni, P., Politi, A., Zoumpoulakis, P., & Iliodromitis, E. (2006). Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues. Bioorganic & Medicinal Chemistry, 14(13), 4353-4360.

[6]. Patel, M. R. (2010). Synthesis and Evaluation of Aniline Derivatives of Biphenyl-2- Carboxylicacid as an Antihypertensive Agent (Doctoral dissertation, Institute of Pharmacy, Nirma University, A'bad).

[7]. Pijeira, M. S. O. (2019). Synthesis of Fluorine-18- Labeled Losartan Analogs as Novel Positron Emission Tomography Tracers for Cancer Imaging. Sao Paulo.

[8]. Shiota, T., Yamamori, T., Sakai, K., Kiyokawa, M., Honma, T., Ogawa, M., & Nakajima, S. (1999). Synthesis and structure-activity relationship of a new series of potent angiotensin II receptor antagonists: Pyrazolo [1, 5-α] pyrimidine derivatives. Chemical and Pharmaceutical Bulletin, 47(7), 928-938.

[9]. Tadwee, I., & Shahi, S. (2018). Formulation development of losartan potassium immediate release tablets and process optimization using SeDeM expert system. Journal of Applied Pharmaceutical Science, 8(2), 033-043.

[10]. Thakur, R. R., Sharma, A., & Kashiv, M. (2011). Formulation, evaluation and optimization of mouth dissolving tablets of losartan potassium: A cost effective antihypertensive drug. Journal of Pharmacy Research, 4(7), 2294-96.

Efficient Synthesis of Losartan Potassium: An Improved Two-Step Method

Abstract

Keywords

How to Cite this Article?

References

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