Orally disintegrating tablets (ODTs) represent a widespread advancement in drug delivery, in particular for patients with swallowing problems, together with the elderly aged and pediatric populations. Those formulations dissolve or disintegrate swiftly inside the mouth, allowing the drug to be absorbed without the need for water, enhancing affected patient compliance, and supplying convenient dosing. The improvement of ODTs carries various strategies, which include freeze-drying, direct compression, and sublimation, every designed to optimize the rapid disintegration and bioavailability of the energetic pharmaceutical factor (API). Key demanding situations in the ODT formula include attaining a sensitive balance between pill hardness and porosity to preserve mechanical integrity even ensuring rapid dissolution. This calls for the careful choice of excipients such as super disintegrates, which boost up the breakup of the tablet, and binders that provide structural support. Advanced methods, consisting of 3D printing and nanotechnology, also are being explored to enhance the customization and efficiency of ODTs for personalized medication. The blessings of ODTs extend beyond patient convenience, as additionally, they facilitate quicker onset of motion and extra therapeutic effectiveness, particularly for medicines where instantaneous alleviation is vital. However, challenges like stability, taste masking, and packaging remain to impact the improvement and giant use of ODTs. Future studies objectives to cope with those limitations, making ODTs a promising alternative in both acute and chronic treatment plans.