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Chemical Biology: What is its Role in Drug Discovery?

Rehan Haider*, Asghar Mehdi**, Geetha Kumari Das***, Zameer Ahmed Khanzada****, Sambreen Zameer Khanzada*****

* Department of Pharmacy, University of Karachi, Pakistan.

** Department of Pharmacology, Fazaia Ruth Pfau Medical College Air University, Karachi, Pakistan.

*** OPJS University, Churu, Rajasthan, India.

****-***** Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan.

Periodicity:May - August'2024

Abstract

Chemical biology is a multidisciplinary subject that combines ideas from chemistry and biology to investigate the molecular mechanisms underlying physiological and pathological tactics. In drug discovery, chemical biology plays a pivotal function in elucidating the difficult interactions among small molecules and organic macromolecules, presenting essential insights that guide the improvement of novel healing agents. This study explores the fundamental contributions of chemical biology to drug discovery, emphasizing its impact on the right track identity, validation, and optimization. Chemical biology strategies allow the identification of capacity drug goals by way of probing the tricky community of molecular interactions within residing structures. Through the usage of chemical probes and revolutionary screening methods, this study selectively modulates unique organic pathways. Once identified, those targets undergo rigorous validation using chemical equipment that provides a precise and systematic assessment of their organic relevance. Moreover, chemical biology facilitates the optimization of lead compounds into drug applicants by offering precise information on shape-activity relationships and ability off-target results. This study includes the design and synthesis of small molecules that selectively engage with the goal, maximizing healing efficacy while minimizing adverse results. The combination of chemical biology strategies in drug discovery complements the efficiency of the drug development pipeline, accelerating the transition from goal identity to the hospital.

Keywords

Chemical Biology, Chemistry, Biology, Drug Goal Identification, Goal Validation, Phenotyping Screening, Drug Discovery, Healing Agents.

How to Cite this Article?

Haider, R., Mehdi, A., Das, G. K., Khanzada, Z. A., and Khanzada, S. Z. (2024). Chemical Biology: What is its Role in Drug Discovery? i-manager’s Journal on Chemical Sciences, 4(2), 31-49.

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