Implanted Drug Delivery Systems for Control of Chronic Pain

Rehan Haider*
Periodicity:September - December'2024

Abstract

Implanted drug delivery systems (IDDS) have emerged as a promising strategy for managing chronic pain, offering precise and sustained drug administration to achieve optimal pain relief while minimizing adverse effects. This abstract reviews the key aspects of IDDS in the context of chronic pain control. Chronic pain, characterized by its persistence over extended periods, presents a significant challenge in medical practice due to its complex and multifaceted nature. Traditional oral medication often falls short of providing consistent pain relief while avoiding systemic side effects. IDDS addresses these limitations by delivering drugs directly to the target site, bypassing first-pass metabolism, and maintaining steady therapeutic concentrations. IDDS consists of an implantable device that houses a reservoir of the chosen medication, connected to a catheter for drug release. The release rate can be programmed and adjusted according to the patient's needs. Commonly used drugs include opioids, local anesthetics, and anti-inflammatory agents. The implantation procedure requires surgical expertise but offers the advantage of long-term pain management, reducing the need for frequent dosing. The efficacy of IDDS in chronic pain control has been demonstrated in various conditions such as cancer pain, neuropathic pain, and failed back surgery syndrome. By providing sustained drug delivery, IDDS ensures consistent pain relief, potentially improving patients' quality of life and reducing the development of tolerance and dependence. However, challenges include the risk of infection, device malfunction, and the invasiveness of the implantation procedure.

Keywords

Implanted drug delivery systems, chronic pain, sustained drug administration, pain relief, adverse effects, implantable device, drug release, opioids, local anesthetics, anti-inflammatory agents, efficacy, quality of life, tolerance, dependence, infection, device malfunction, implantation procedure, technology advancement.

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