Burns are a significant global health issue, with the World Health Organization (WHO) reporting nearly 180,000 deaths annually due to burns. In India alone, nearly 1 million people suffer from moderate to severe burns each year. To address this, skin grafting using tilapia fish skin has emerged as a promising solution. This study provides an overview of the technique and its outcomes in burn injury treatment. Skin grafting is a medical procedure that involves harvesting healthy skin to replace damaged tissue, considering factors such as anti-inflammatory properties, durability, and aesthetic matching. Burns can severely damage human skin, resulting in prolonged healing times and potential scarring. Tilapia fish skin grafting is an innovative clinical approach that has been increasingly used to treat burn injuries. This method has shown promising clinical results, offering better outcomes in burn injury recovery.