Disease detection in agricultural crops, such as Solanum tuberosum L. (potato), is of utmost importance to ensure crop health and maximize yield. Traditional methods for disease detection in potatoes rely on manual inspection, which can be time-consuming and prone to human error. Image processing and machine learning techniques have shown promise in automating disease detection processes. This study proposes a novel approach for disease detection in Solanum tuberosum L. by leveraging image fusion techniques. The proposed method involves the fusion of multiple images of potato plants, acquired using different sensors or imaging modalities, to create a comprehensive and informative representation of the crop. Image fusion methods, such as discrete wavelet transform and continuous wavelet transform, are employed to combine the spectral and spatial information from the images effectively. The different image fusion rule is applied to the input images and resultant fused images, where relevant features are extracted to distinguish between healthy and diseased potato plants. The training dataset comprises diverse samples of both healthy and diseased potato plants, captured under various environmental conditions and disease stages. The performance of the proposed disease detection system is evaluated using standard metrics such as entropy. The results demonstrate the effectiveness of the image fusion approach in accurately identifying diseased potato plants, achieving high detection accuracy and generalization capabilities. The potential benefits of this paper include providing farmers and agricultural experts with an efficient and reliable tool for early disease detection in potato crops. Early detection can lead to timely intervention, minimizing crop losses and optimizing agricultural practices. The proposed methodology also lays the groundwork for future research in using advanced image processing techniques and machine learning algorithms for disease detection in other agricultural crops, contributing to the overall improvement of crop management and food security.