Pain management is a critical aspect of nursing care, directly influencing patient outcomes and quality of life. This paper explores the nursing perspective on pain management, emphasizing holistic and patient-centered approaches that are essential for effective pain relief. Nurses play a pivotal role in pain assessment, utilizing various tools and techniques to evaluate pain intensity, location, and its impact on daily activities. The integration of pharmacological and nonpharmacological interventions is crucial in developing comprehensive pain management plans. Pharmacological approaches include the administration of analgesics, opioids, and adjuvant therapies, tailored to individual patient needs and clinical conditions. Non-pharmacological strategies, such as cognitive-behavioral therapy, relaxation techniques, and physical modalities, are also highlighted for their significant contributions to pain relief. This paper underscores the importance of continuous education and training for nurses to stay updated on evolving pain management practices and to ensure the safe and effective use of pain relief modalities. Additionally, it addresses the challenges nurses face, such as balancing the risks of opioid use, managing patient expectations, and overcoming barriers to accurate assessment in diverse populations. By adopting a collaborative approach that includes patients, families, and multidisciplinary teams, nurses can enhance the effectiveness of pain management and contribute to improved patient outcomes. Future research directions are suggested to address gaps in knowledge and practice, ensuring that pain management strategies continue to evolve and improve.