Pulmonary and respiratory well-being is an important area of clinical studies, especially given the growing prevalence of breathing illnesses such as Chronic Obstructive Pulmonary Disease (COPD), asthma, and Acute Respiratory Distress Syndrome (ARDS). Antioxidants and nutraceuticals have garnered significant attention for their therapeutic roles in managing these conditions. This paper evaluates the current evidence of the efficacy of various antioxidants and nutraceuticals, including vitamins C and E, N-acetylcysteine, omega-3 fatty acids, and polyphenols, in improving respiratory health. Antioxidants help reduce oxidative stress, a primary factor in the pathogenesis of many respiratory diseases. Nutraceuticals provide a diet-based approach to support pulmonary function and reduce inflammation. Clinical studies have shown that these compounds can enhance lung function, decrease inflammation, and improve the overall quality of life in patients with respiratory issues. However, results are mixed, and larger-scale randomized controlled trials are needed to confirm their benefits. Additionally, the bioavailability and optimal dosing of these compounds remain areas of ongoing research. Despite these challenges, incorporating antioxidants and nutraceuticals into general respiratory care shows promise as a complementary approach to pharmacotherapy. This overview emphasizes the need for continued research into the specific mechanisms through which these compounds exert their effects, leveraging their inherent characteristics and potential for integration into clinical practice for the treatment of respiratory disorders.