It is challenging for obese individuals to effectively manage their condition, as weight-loss methods require significant physical effort, lifestyle changes, and a high level of patient commitment. Gastric phase regulation and satiety are influenced by the activation of volume-dependent vagal signaling through gastromechanical receptors, which also monitor gas formation in the body. This method for stimulating the luminal cell membrane precisely activates these receptors, inducing stretch responses within the stomach and triggering a vagal reflex equivalent to mechanical distension. This study, the Buzzing Ingestible Bio-Electronic Stimulator (VIBES) pill, is an easily ingestible device that activates the body's sensors and stimulates mucosal receptors using gentle vibrations. This process promotes the production of serotonin and induces hormonal responses that mimic a satiated metabolic state. This study evaluated the effectiveness of VIBES using 109 hog meals, which resulted in significant therapeutic outcomes, including a ~40% reduction in dietary intake (P < 0.0001) and reduced weight gain (P < 0.05) compared to untreated control animals. Mechanoreceptor biology offers promising opportunities to improve dietary management for individuals with metabolic and dietary challenges.