Immunotherapy, a promising cancer treatment method, faces challenges such as off-target effects and limited efficacy. Researchers are utilizing nanotechnology to enhance the accuracy and effectiveness of immunotherapy. In a clinical trial, nanoparticles were used to directly carry immunomodulatory drugs to tumor locations, enhancing cytotoxic T cell activation and preventing tumor growth. Patients receiving nanoparticle-enhanced immunotherapy experienced longer progression-free survival times and higher response rates than those receiving standard immunotherapy alone. This study demonstrates how nanotechnology is revolutionizing immunotherapy approaches for focused cancer treatment.