Fibroid uterus, also known as Uterine leiomyoma, represents a common gynecological disorder affecting women, particularly those in their reproductive years. This paper presents a case study focusing on the clinical manifestation, diagnosis, management, and nursing care of a 43-year-old woman with fibroid uterus. Fibroids, benign neoplasms of the uterine wall, are classified based on their location within the uterus. Risk factors for fibroid development include early puberty, obesity, genetic predisposition, and oral contraceptive use. Diagnosis often involves ultrasound imaging, revealing characteristic features such as heterogeneous hypoechoic lesions. Management options range from medical to surgical interventions, with considerations for patient age, fertility preservation, and symptom severity. Surgical procedures like myomectomy and hysterectomy may be necessary, while non-surgical alternatives such as uterine artery embolism and myolysis offer alternatives. Nursing care focuses on pain management, nutritional support, infection prevention, and patient education. Early detection and appropriate management are essential to mitigate the risk of complications and preserve fertility in affected women.