The integration of online and face-to-face instruction, known as blended learning, has gained traction in science education, particularly in tertiary settings. This study investigates the efficacy of a blended learning approach on academic achievement among tertiary-level chemistry students. A bespoke blended learning curriculum was devised for two chemistry units, and a randomized two-group experimental design was implemented. Sixty-five students were randomly assigned to either the treatment group, receiving blended learning, or the control group, receiving traditional lecture-based instruction. An independent samples t-test was conducted to compare post-test scores between the groups, controlling for prior knowledge using pretest scores as a covariate. Results indicate that students in the blended learning group attained significantly higher post-test scores (M = 81.53, SD = 10.23) compared to their counterparts in the control group (M = 74.33, SD = 9.04), with a t-value of (63) = 2.85, and p = .006. This study underscores the potential of well-designed blended instruction in enhancing chemistry education at the tertiary level. Further investigations into optimal blend ratios and implementation strategies are recommended for comprehensive insights.