This paper focuses on the major features of Lydia Hall's theory and Henderson's theory. Henderson's Need Theory consists of fourteen components that illustrate how to meet the physical, emotional, spiritual, and social needs of a person holistically, while Lydia Hall's theory consists of three interrelated circles: care, core, and cure circles. Both theories can assist healthcare professionals, particularly nurses, in delivering holistic care to patients. The research extends to a detailed case study involving a 66-year-old woman diagnosed with COVID-19, highlighting the practical application of both theories in addressing the physical, emotional, spiritual, and social needs of the patient. Virginia Henderson's emphasis on meeting fundamental patient needs and Lydia Hall's patient-centered approach with the care, core, and cure components are strategically applied to enhance the quality of nursing care. The analysis explores the strengths and limitations of each theory, offering insights into their applicability in diverse healthcare scenarios. The paper concludes by emphasizing the importance of incorporating these nursing theories into practice to ensure a holistic and patient-centered approach.