Keratocystic Odontogenic Tumors (KOTs), otherwise known as odontogenic keratocysts, are benign cysts of odontogenic origin with a destructive clinical behavior, including a high recurrence rate. Multiple KOTs in the maxillofacial region are commonly associated with syndromes. The reported occurrence of non-syndromic multiple KOTs are very rare. This case report presents a patient with multiple cystic lesions in both the maxilla and mandible, histologically proven to be KOTs, without any systemic manifestations.