The oral mucosa is commonly involved in immune-mediated lesions, of which the most common are recurrent aphthous stomatitis, oral lichen planus, and oral submucous fibrosis. The present study aimed to evaluate anxiety, depression, somatic symptoms, and social dysfunction using the General Health Questionnaire-28 in patients with these mucosal lesions. The association between psychiatric morbidity and chronic oral mucosal diseases has been sparsely studied, and this study aims to address this gap.