The purpose of this study is to report a clinical case of a 55-year-old female patient with a Peripheral Ossifying Fibroma (POF) in the maxilla with a history of endodontic treatment. POF is a non-neoplastic enlargement of the gingiva that is classified as an active hyperplastic inflammatory lesion. These lesions originate from the cells of the periodontal ligament, appear in the gingival tissue, and are located anterior to the molars and in the maxilla, close to the periodontal ligament. POF mainly affects women in the second and third decades of life. The lesion may be present for months to years before treatment, depending on the degree of ulceration, discomfort, and interference with function. The patient was studied with a complete intra or extraoral examination, radiographic analysis, hematologic and histopathological examination, and underwent surgical management, followed by postoperative follow-up.