Oral cancer has long been considered a disfiguring and deadly disease of the oral cavity. Despite an increase in therapeutic modalities, the prognosis is poor due to a lack of early diagnosis and detection. To ensure timely care and a better prognosis, a mass screening procedure and rapid diagnostic test are required. Lab on a chip is a promising technology that can replace all laboratory procedures with a miniaturized chip that can identify cancer biomarkers at all levels, from gene profiling to proteins in cancer cells.