The fulminant fungal infection, mucormycosis, is an opportunistic disease that causes significant morbidity and mortality in susceptible individuals. The rhino-cerebral structures are often involved, with devastation of the facial hard and soft tissues. This infection overwhelms patients who are already compromised, such as those with diabetes mellitus, hematologic malignancy, renal failure, or immunosuppression. Here, we describe a case of rhino-cerebral mucormycosis in a patient with uncontrolled diabetes and renal failure who was surgically treated.