Rhino-orbital mucormycosis is a rare, but life threatening infection that generally occurs in patients with immune deficiency. As such the condition is a medical emergency. Early recognition and treatment are essential because it may lead to death within a few days. Fungal infections of the eye are uncommon but are being seen with increasing frequency in patients with immune deficiency. Current therapy for the invasive disease includes treating the underlying predisposing factors, antifungal therapy, and surgical debridement of the affected tissues. Early recognition of the disease and treating the underlying cause of mucormycosis are key to improving outcomes.