Bisphosphonates are a class of drugs that are widely used to inhibit bone resorption in various bone diseases. Due to their increased affinity to bone and ability to increase osteoblastic differentiation while inhibiting osteoclastic activity, bisphosphonates are also used as host modulation agents in periodontal diseases. Bisphosphonates have been shown to prevent bone destruction in osteoporosis by altering the host response. The purpose of this paper is to discuss the implications of bisphosphonates in periodontics and their potential complications.