The increased use of all-ceramic crowns provides a rationale for tooth-colored cores. The restoration of endodontically treated teeth requires the fabrication of a post and core to provide retention and support for the final crowns. The purpose of this in-vitro study was to evaluate the fracture resistance of endodontically treated teeth restored with three all-ceramic post and core systems: prefabricated zirconia post, milled zirconia post and core, and pressable ceramic post and core of 1.7 mm diameter. Three different methods were used to fabricate all-ceramic post-and-core restorations: pressing IPS Empress cores directly to prefabricated zirconia posts, custom-milled one-piece post-and-core restorations, and pressable ceramic post and core fabricated by the lost wax technique. Ten samples were prepared with each of the three methods. Each specimen was subjected to load-to-fracture in a universal testing machine (Instron model 3345) at a 130-degree angle, and the maximum load at failure was recorded. The highest breaking load was recorded for the prefabricated zirconia group (638.67±0.81), which showed significantly better results compared to the milled zirconia group (415.00±0.89) and the pressable ceramic group (375.00±1.57), respectively. These differences were statistically significant at P<0.05. The prefabricated zirconia post with pressable ceramic core (Cosmo post) exhibited higher fracture resistance, making it the ideal material of choice among the tested groups. The milled zirconia also showed satisfactory results. The pressable ceramic post and core can also be included in prosthodontics for the restoration of anterior teeth. It is comparatively cheap and easily fabricated by the lost wax technique.