Periapical diseases are induced as a result of involvement of oral bacteria. Therefore, mere surgical removal of the periapical lesions without proper root canal disinfection and obturation will not result in the healing of periapical tissues. This case series presents non-surgical endodontic management of large periapical pathosis with calcium hydroxide intra-canal medicament. Significant bone formation was seen at the periapical region during periodic checkup visits. Thus, conventional endodontic therapy in combination with calcium hydroxide as an intra-canal medicament contributed to the effective healing of periapical lesions.