Saliva has been portrayed as a unique, yet complex body fluid. Saliva, a biofluid, is readily accessible through non-invasive methods. The discovery of saliva as a diagnostic aid in oral diseases has been a major milestone in dentistry. Saliva contains various proteins, enzymes, and hormones that are used as markers for oral diseases. This article highlights the importance of saliva as a diagnostic key and briefly reviews various salivary biomarkers used in the diagnosis of various oral lesions.