Aspergillosis is a term used to describe a range of diseases resulting from infection with fungi belonging to the Aspergillus genus. The most common types include allergic bronchopulmonary aspergillosis, pulmonary aspergilloma, and invasive aspergillosis. Aspergillosis typically affects individuals who have compromised immune systems due to disease or immunosuppressive medications, and it is a leading cause of death in patients with acute leukemia and those who undergo hematopoietic stem cell transplantation. This report describes a case of invasive aspergillosis in a 76-year-old male with a perforation in the anterior hard palate. The patient was diagnosed and treated by maxillofacial surgeons.