Behcet's Disease is a multisystem inflammatory disorder in which recurrent oral ulceration is associated with genital ulceration, ocular lesions, pustules, and/or uveitis. The etiology of Behcet's Disease is unknown, and diagnosis is based on clinical grounds only, as there are no established laboratory tests. Treatment options range from topical steroid application to the use of systemic steroid and immunosuppressant agents (e.g. azathioprine, cyclosporine A). Here, we present a rare case of Behcet's syndrome in a 22-year-old man managed successfully with systemic administration of corticosteroids and thalidomide at our department. The patient has been on follow-up for the last three months but later lost follow-up. No recurrence of oral and genital ulcers has occurred during the follow-up period. Behcet's syndrome is an autoimmune condition with no reported cure, and this therapy is aimed at providing symptomatic relief of local symptoms.