Biopsies are an important diagnostic tool for the diagnosis of lesions ranging from simple periapical lesions to malignancies. Planning prior to performing a biopsy is essential. It will be beneficial to the receiving pathologist in reaching a helpful and meaningful diagnosis, and therefore, ultimately and more importantly, to the patient. This paper presents various types of biopsies, discusses their advantages, disadvantages, biopsy techniques, and specimens, as well as how to overcome potential issues.