Pyogenic Granuloma (PG) is a relatively common, rapidly enlarging, non-neoplastic, reactive oral lesion that frequently occurs in the gingiva, ranging in size from a few millimeters to several centimeters. Smaller lesions are usually asymptomatic, whereas larger ones may cause various discomforts to the patient, such as hindrance in speech, inability to close the mouth, and profuse bleeding. In this report, we present the case of a 52-year-old woman with a huge pyogenic granuloma that resulted in an inability to close her mouth. Despite the excision of the lesion, it recurred after one month, with no evidence of any local irritational factors.