In this research article, a compact plus-shaped L-shaped slotted microstrip patch antenna is proposed for various applications, including the Global System for Mobile communication (GSM), Wireless Local Area Network (WLAN), Worldwide Interoperability for Microwave Access (WiMAX), and C-band X-band applications. The rectangular patch includes a plus-shaped slot, with an L-shaped slot cut along it, providing enhanced bandwidth and gain with multiband resonance. The radiation pattern of the proposed antenna is also better. The proposed antenna is capable of operating in four bands: (2.0 – 2.5 GHz)/2.2 GHz for GSM and WLAN applications, (3.6 – 3.9 GHz)/3.7 GHz for Wireless Fidelity (WiFi) and WiMAX applications, (6.7 -7.4 GHz)/7.1 GHz, and (9.1 – 10.8 GHz)/10 GHz for C- and X-band applications. The impedance bandwidth is 22.7%, 8.1%, 10%, and 17% for each respective frequency range. A parametric analysis of different dimensions, Voltage Standing Wave Ratio (VSWR), surface current distribution, and radiation pattern is presented to verify and validate the design parameters in each sections.