Laser therapy and ultrasound waves play an important role in accelerating the healing process of different types of tissues lesions including bone tissue. The effect of both laser and ultrasound on bone fracture healing was studied and evaluated in this paper. The Nd:YAG (1064 nm wavelength, 135 mW power) and diode laser (637 nm wavelength, 250 mW power) lasers with ultrasound of 1 MHz frequency and  50 mW/cm² power intensity were used in this study. A preliminary study on 12 young male albino rates was performed to evaluate the attenuation coefficients of the laser and ultrasound together as they passing through the tissues of skin, muscle and bone. This study showed how much the ultrasound increases the penetration of laser power through these tissues. The laser energy distribution contours in the skin and muscle to reach the bone were also calculated mathematically using finite difference equations on MATLAB version7. The histological assessments of using Nd:YAG laser with ultrasound  on the bone fracture  healing  showed faster healing  than using laser alone and both of these results were better than the healing without laser irradiation.