The impact of a variety of physical variables on Casson flow fluid through a vertical plate is investigated and, in this research, heat source/sink, radiation, diffusion thermo and chemical reaction has been included. Perturbation procedure is accustomed to solve non-dimensional multivariable governing equations. Graphical representations are habituated to explain the behaviour of concentration, temperature, and velocity for many characteristics and physical constants such as the Casson parameter (γ), Magnetic parameter (M), Grashof number (Gr), Prandtl number (Pr), modified Grashof number (Gm), Radiation parameter (R), heat sink parameter (Q), Dufour parameter (Du), influence of concentration, temperature, and velocity. The most important finding of the study is that when Dufour values rises, velocity and temperature rises as well. Tables are also used to compute the skin friction, Nusselt and Sherwood numbers.