The removal of lead from wastewater using Borassus flabellifer coir powder has been investigated effectively. The effect of adsorption parameters like initial lead concentration (20-100 mg/L), pH (7-9), and adsorbent dosage (4-6 g/L) on lead adsorption were examined using Box-Behnken design (BBD) in response surface methodology. The full response surface estimation and experimental design have been carried out by the Box-Behnken Design methodology. According to design model, 15 trials were run. The maximum removal of lead from waste water of 20 mg/L at optimum conditions was as follows: biomass dosage (6.0572 g/L), pH (9.4547) and initial lead concentration (55.7893 mg/L). The BBD model has been used effectively for the removal of lead from wastewater based on relatively high correlation coefficient (R2 =0.922) between the BBD design model and the experimental data using Borassus flabellifer coir powder.